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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Asakura W, Matsumoto K, Watanabe H

Division of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.

Gen Pharmacol. 1995 Oct;26(6):1225-8. doi: 10.1016/0306-3623(95)00024-u.

Effect of REM sleep (REMs) deprivation treatment on clozapine response in the forced swimming test was investigated. 2. Clozapine significantly increased the swimming activity in REMs-deprived mice at a dose of 5 mg/kg (i.p.) which did not affect the activities in the control groups. 3. Physostigmine (0.3 mg/kg, i.p.), an acetylcholinesterase inhibitor, blocked the increasing effect of 5 mg/kg clozapine on swimming activity in REMs-deprived animals. 4. These results suggest that the REMs deprivation treatment-induced enhancement of effect of clozapine on swimming activity is mediated by the functional change of central cholinergic system following the treatment.

研究了快速眼动睡眠（REMs）剥夺治疗对强迫游泳试验中氯氮平反应的影响。2. 氯氮平以5毫克/千克（腹腔注射）的剂量显著增加了REM剥夺小鼠的游泳活动，而该剂量对对照组的活动没有影响。3. 乙酰胆碱酯酶抑制剂毒扁豆碱（0.3毫克/千克，腹腔注射）阻断了5毫克/千克氯氮平对REM剥夺动物游泳活动的增强作用。4. 这些结果表明，REMs剥夺治疗诱导的氯氮平对游泳活动作用的增强是由治疗后中枢胆碱能系统的功能变化介导的。

Asakura W, Matsumoto K, Watanabe H

Division of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.

Gen Pharmacol. 1995 Oct;26(6):1225-8. doi: 10.1016/0306-3623(95)00024-u.

Effect of REM sleep (REMs) deprivation treatment on clozapine response in the forced swimming test was investigated. 2. Clozapine significantly increased the swimming activity in REMs-deprived mice at a dose of 5 mg/kg (i.p.) which did not affect the activities in the control groups. 3. Physostigmine (0.3 mg/kg, i.p.), an acetylcholinesterase inhibitor, blocked the increasing effect of 5 mg/kg clozapine on swimming activity in REMs-deprived animals. 4. These results suggest that the REMs deprivation treatment-induced enhancement of effect of clozapine on swimming activity is mediated by the functional change of central cholinergic system following the treatment.

研究了快速眼动睡眠（REMs）剥夺治疗对强迫游泳试验中氯氮平反应的影响。2. 氯氮平以5毫克/千克（腹腔注射）的剂量显著增加了REM剥夺小鼠的游泳活动，而该剂量对对照组的活动没有影响。3. 乙酰胆碱酯酶抑制剂毒扁豆碱（0.3毫克/千克，腹腔注射）阻断了5毫克/千克氯氮平对REM剥夺动物游泳活动的增强作用。4. 这些结果表明，REMs剥夺治疗诱导的氯氮平对游泳活动作用的增强是由治疗后中枢胆碱能系统的功能变化介导的。