Spierings E L, Dzoljic M R, Godschalk M
Pharmacology. 1977;15(6):551-6. doi: 10.1159/000136734.
The effect of clozapine on the sleep pattern in the rat was studied after a single injection (2.5--20 mg/kg) and after daily administration for 11 consecutive days (2 X 20 mg/kg/day). After a single injection clozapine significantly suppressed REM sleep in a dose-related way, leaving slow wave sleep (SWS) unchanged. Follwing chronic administration, however, clozapine exerted its most prominent effect on SWS, the enhancement of which persisted for at least 3 days after discontinuation of treatment. REM sleep decreased with the development of tolerance and in the absence of rebound phenomena. The results are discussed in the light of disturbances in brain monoamines and the tolerance these amines developed to repeated administration of clozapine.
研究了单次注射（2.5 - 20毫克/千克）及连续11天每日给药（2×20毫克/千克/天）后氯氮平对大鼠睡眠模式的影响。单次注射后，氯氮平以剂量相关的方式显著抑制快速眼动睡眠（REM睡眠），而慢波睡眠（SWS）未发生变化。然而，长期给药后，氯氮平对慢波睡眠产生了最显著的影响，在停药后这种增强作用持续了至少3天。快速眼动睡眠随着耐受性的发展而减少，且不存在反跳现象。根据脑单胺类物质的紊乱以及这些胺类物质对氯氮平重复给药产生的耐受性对结果进行了讨论。
