奥美拉唑对人自然杀伤细胞活性的影响。
The effect of omeprazole on human natural killer cell activity.
作者信息
Aybay C, Imir T, Okur H
机构信息
Gazi University, Faculty of Medicine, Department of Microbiology, Besevler, Ankara, Turkey.
出版信息
Gen Pharmacol. 1995 Oct;26(6):1413-8. doi: 10.1016/0306-3623(94)00301-3.
PMID:7590140
Abstract
- Omeprazole, an antiulcer drug, inhibits the gastric acid pump via blocking the parietal cell (H+ + K+)-ATPase. Omeprazole was also reported to have an inhibitory action on polymorphonuclear neutrophil activities. In the present study the potential effect of omeprazole on human natural killer cell (NK) activity was investigated. 2. Omeprazole decreased NK cytotoxic activity in a dose-dependent manner. 3. Degraded omeprazole showed a similar action. 4. In vitro NK inhibitory action of omeprazole and its acid-degraded form was observed at the concentrations equal and higher than 18 microM (micromolar). 5. NK inhibitory action of omeprazole was recovered to 75% by washing away of the agent. 6. Omeprazole decreased the conjugate formation of effector and target cells by 50% at the concentration of 288 microM
摘要
- 奥美拉唑是一种抗溃疡药物，通过阻断壁细胞（H⁺+K⁺）-ATP酶来抑制胃酸泵。据报道，奥美拉唑对多形核中性粒细胞活性也有抑制作用。在本研究中，对奥美拉唑对人自然杀伤细胞（NK）活性的潜在影响进行了研究。2. 奥美拉唑以剂量依赖的方式降低NK细胞的细胞毒性活性。3. 降解后的奥美拉唑表现出类似的作用。4. 在浓度等于或高于18微摩尔（μM）时，观察到奥美拉唑及其酸降解形式在体外具有NK抑制作用。5. 通过洗去该药物，奥美拉唑的NK抑制作用恢复到75%。6. 在浓度为288微摩尔时，奥美拉唑使效应细胞与靶细胞的结合形成减少了50%
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