Allen N E, Hobbs J N
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
FEMS Microbiol Lett. 1995 Oct 1;132(1-2):107-14. doi: 10.1111/j.1574-6968.1995.tb07819.x.
Bacitracin and other antibiotics that inhibit late stages in peptidoglycan biosynthesis induce vancomycin resistance in a high-level, inducibly vancomycin-resistant strain of Enterococcus faecium. Exposure to bacitracin led to synthesis of the lactate-containing UDP-MurNAc-pentadepsipeptide precursor required for vancomycin resistance. These findings indicate that inhibition of peptidoglycan biosynthesis can lead to induction of vancomycin resistance and raise the possibility that multiple signals may serve to induce resistance.
杆菌肽和其他抑制肽聚糖生物合成后期的抗生素会在一株高水平、可诱导性耐万古霉素的屎肠球菌中诱导产生万古霉素耐药性。接触杆菌肽会导致合成耐万古霉素所需的含乳酸的UDP-胞壁酰五肽前体。这些发现表明，抑制肽聚糖生物合成可导致万古霉素耐药性的诱导，并增加了多种信号可能诱导耐药性的可能性。
