Vorob'eva L I, Cherdyntseva T A, Abilev S K
Genetika. 1995 Jul;31(7):901-7.
It was shown that cell extracts and cells of Streptococcus faecalis decrease the mutagenic effect of 2-nitrofluorene in Salmonella typhimurium strain TA1538 by 73 and 48%, respectively. Cell extracts and cells of Bifidobacterium bifidum and Propionibacterium shermanii exhibited weak antimutagenic activity. No antimutagenic effect was found in Escherichia coli AB1157, Lactobacillus delbrueckii, or Streptococcus thermophilus. Antimutageneicity of the cell extract of Str. faecalis is both associated with extracellular factors interacting with 2-nitrofluorene (desmutagenesis) and with factors affecting intracellular processes of mutagen biotransformation and mutation induction. Thiol compounds produced by growing Str. faecalis may be desmutagenic factors. A relatively heat-stable substance or substances of a peptide nature with a MM less than 12 kDa are antimutagenic factors affecting intracellular processes of mutagenesis.
结果表明，粪肠球菌的细胞提取物和细胞分别使鼠伤寒沙门氏菌TA1538菌株中2-硝基芴的诱变作用降低了73%和48%。两歧双歧杆菌和谢氏丙酸杆菌的细胞提取物和细胞表现出较弱的抗诱变活性。在大肠杆菌AB1157、德氏乳杆菌或嗜热链球菌中未发现抗诱变作用。粪肠球菌细胞提取物的抗诱变作用既与与2-硝基芴相互作用的细胞外因子（去诱变作用）有关，也与影响诱变剂生物转化和突变诱导细胞内过程的因子有关。生长中的粪肠球菌产生的硫醇化合物可能是去诱变因子。一种相对耐热的物质或具有小于12 kDa分子量的肽性质的物质是影响诱变细胞内过程的抗诱变因子。
