[Association of nucleotide substitutions in the cytochrome b gene and regulatory region in types of human mitochondrial DNA].

Nucleotide sequences of the cytochrome b gene fragment of the mitochondrial DNA (mtDNA) between primers b1 and b2 were determined in eleven eastern Slavs. The group analyzed consisted of samples that differed in the hypervariable segment I (HVSI) of the mtDNA control region by one to seven nucleotide substitutions. Three types of the b1-b2 segment of the cytochrome b gene were registered. A lack of correlation between diversity in the coding (cytochrome b gene) and noncoding (HVSI) regions of mtDNA was shown. Association between substitutions at positions 14905 bp in cytochrome b gene, and also 16126 bp and 16294 bp in the control region of mtDNA, was found.