May A, Selmaier M, Hochberger J, Gossner L, Mühldorfer S, Hahn E G, Ell C
Department of Medicine I, University of Erlangen-Nuremberg, Germany.
Gut. 1995 Sep;37(3):309-13. doi: 10.1136/gut.37.3.309.
Thirty patients with incurable malignant obstruction of the oesophagus and cardia were treated with self expanding oesophageal memory metal stents (Ultraflex) in a prospective study. The endoprostheses were successfully placed in all patients. Within one week after implantation dysphagia had improved in 25 of 30 patients (83%). Stent expansion was incomplete within one week after implantation in 12 of 30 patients (40%). After an average of two dilatation sessions eight of 12 stents had expanded completely. Five patients complained of retrosternal pain and three of them suffered from heartburn over several days despite acid inhibition. Major problems in the follow up period occurred in 10 of 30 patients (30%) and included late perforation (one) and tumour ingrowth/overgrowth (nine). All of these complications were treated endoscopically. Improvement of the dysphagia of the patients with tumour ingrowth/overgrowth lasted for about eight weeks (median; range: 2-38 weeks). Until November 1994 six of 30 patients were still alive with a survival time of 309 days (median; range: 103-368 days). It is concluded that oesophageal memory metal stents are easy to implant, prove effective in the palliation of malignant oesophageal obstructions, and have a low risk of severe complications. The only disadvantages are that incomplete initial stent expansion as well as tumour ingrowth/overgrowth occurred in nearly one third of the patients.
一项前瞻性研究中,对30例无法治愈的食管和贲门恶性梗阻患者采用自膨式食管记忆金属支架(Ultraflex)进行治疗。所有患者均成功植入内支架。植入后一周内,30例患者中有25例(83%)吞咽困难得到改善。30例患者中有12例(40%)在植入后一周内支架扩张不完全。平均经过两次扩张治疗后,12个支架中有8个完全扩张。5例患者主诉胸骨后疼痛,其中3例尽管使用了抑酸药物,但仍持续数天出现烧心症状。随访期间,30例患者中有10例(30%)出现严重问题,包括晚期穿孔(1例)和肿瘤长入/过度生长(9例)。所有这些并发症均通过内镜治疗。肿瘤长入/过度生长患者吞咽困难的改善持续约8周(中位数;范围:2 - 38周)。截至1994年11月,30例患者中有6例仍然存活,生存时间为309天(中位数;范围:103 - 368天)。研究得出结论,食管记忆金属支架易于植入,在缓解恶性食管梗阻方面证明有效,且严重并发症风险低。唯一的缺点是近三分之一的患者出现初始支架扩张不完全以及肿瘤长入/过度生长的情况。