Seidman J D
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Gynecol Oncol. 1995 Nov;59(2):283-7. doi: 10.1006/gyno.1995.0023.
Twenty women with ovarian small cell carcinoma of the hypercalcemic type were studied. Mean patient age was 24 years, 11 had hypercalcemia, and the 2-year actuarial survival was 18%; there was only one long-term survivor. Twelve of 15 tumors tested (80%) exhibited p53 protein accumulation by immunohistochemistry, supporting the presence of p53 gene mutations in these tumors. p53 gene mutations may have an important role in the evolution of small cell ovarian carcinomas.
对20例高钙血症型卵巢小细胞癌患者进行了研究。患者平均年龄为24岁，11例有高钙血症，2年精算生存率为18%；仅有1例长期存活者。15个检测肿瘤中有12个（80%）通过免疫组织化学显示p53蛋白积聚，支持这些肿瘤中存在p53基因突变。p53基因突变可能在卵巢小细胞癌的发生发展中起重要作用。
