Förster C, Ostertag H, Schmitt J, Roessner A
Department of Pathology, Hospital Nordstadt, Hanover, Germany.
Gen Diagn Pathol. 1997 Jun;142(5-6):365-70.
Small cell carcinomas of the ovary, hypercalcemic type, are unilateral tumors occurring almost exclusively in young women. 60% of the cases are associated with hypercalcemia. Microscopic examination shows diffuse clusters of small cells and follicle-like spaces. Immunohistochemically, the tumor cells are positive for epithelial and mesenchymal markers, and ultrastructurally they contain an abundance of dilated rough endoplasmatic reticulum and numerous free ribosomes. By DNA-single cell photometry, the neoplastic cells show a diploid DNA-content.
卵巢高钙血症型小细胞癌是几乎仅发生于年轻女性的单侧肿瘤。60%的病例伴有高钙血症。显微镜检查显示小细胞弥漫性聚集及滤泡样间隙。免疫组化显示肿瘤细胞上皮和间充质标志物呈阳性，超微结构显示其含有大量扩张的粗面内质网和众多游离核糖体。通过DNA单细胞光度测定，肿瘤细胞显示二倍体DNA含量。
