Islam M N, Kuroki H, Hongcheng B, Ogura Y, Kawaguchi N, Onishi S, Wakasugi C
Department of Legal Medicine, Osaka University Medical School, Japan.
Forensic Sci Int. 1995 Aug 28;75(1):29-43. doi: 10.1016/0379-0738(95)01765-b.
In order to clarify the effect of methamphetamine (MA) on myocardium, histological, immunohistochemical and electron microscopic changes in the myocardium of rats were examined following daily intraperitoneal administration of MA at a dose of 1 mg per kg body weight for 4, 8, and 12 weeks before sacrifice. Normal saline (NS) was similarly injected for the same period before sacrifice to constitute a control group. Light microscopic changes found in the myocardium of the MA-treated group included atrophy, hypertrophy, patchy cellular infiltration, eosinophilic degeneration and disarray, edema myolysis, fibrosis, and the appearance of vacuoles. Ultrastructurally, nuclei and normal mitochondria had various shapes and there were dilated T tubules and sarcoplasmic reticulum, the accumulation of glycogen granules and fat droplets. Intra- and extra-cellular edema and intramyocytic vacuoles were often found. Withdrawal of MA at the twelfth week in another group of rats evidenced gradual recovery of the myocardial changes, commencing at 3 weeks after withdrawal. Optimism is therefore generated about the possibility of the affected hearts in MA-abuse patients returning towards the normal state if they give up the drug.
为阐明甲基苯丙胺（MA）对心肌的影响，在处死前，对大鼠连续4周、8周和12周每日腹腔注射1mg/kg体重的MA，之后检测大鼠心肌的组织学、免疫组织化学和电子显微镜变化。在处死前同期，对对照组大鼠同样注射生理盐水（NS）。MA处理组大鼠心肌的光镜变化包括萎缩、肥大、散在性细胞浸润、嗜酸性变和排列紊乱、水肿性肌溶解、纤维化以及空泡出现。超微结构上，细胞核和正常线粒体形态各异，T小管和肌浆网扩张，糖原颗粒和脂滴积聚。常可见细胞内和细胞外水肿以及肌细胞内空泡。另一组大鼠在第12周停用MA后，心肌变化从停药后3周开始逐渐恢复。因此，如果滥用MA的患者戒毒，受影响的心脏有可能恢复正常，这让人产生了乐观情绪。
