Perea A, Clemente F, Martinell J, Villanueva-Peñacarrillo M L, Valverde I
Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Madrid, Spain.
Horm Metab Res. 1995 Aug;27(8):372-5. doi: 10.1055/s-2007-979981.
In human isolated adipocytes, glucagon induces a dose dependent increment of the glycerol release, which is already observed at physiological concentrations of the hormone. Furthermore, glucagon at 10(-8) M, significantly stimulates the adenylate cyclase activity in both non-solubilized and solubilized fat plasma membranes, and at already 10(-11) M, a significant increment of the adipocyte cAMP content is observed. These data support previous in vivo positive results indicating that glucagon plays a role in human fat metabolism.
在人体分离的脂肪细胞中，胰高血糖素可诱导甘油释放呈剂量依赖性增加，在该激素的生理浓度下即可观察到这一现象。此外，10(-8) M的胰高血糖素能显著刺激未溶解和已溶解的脂肪细胞膜中的腺苷酸环化酶活性，而在10(-11) M时，即可观察到脂肪细胞中cAMP含量显著增加。这些数据支持了先前的体内阳性结果，表明胰高血糖素在人体脂肪代谢中发挥作用。
