Bagrov A Y, Fedorova O V, Austin-Lane J L, Dmitrieva R I, Anderson D E
Laboratory of Behavioral Sciences, National Institute on Aging, Baltimore, MD 21224, USA.
Hypertension. 1995 Nov;26(5):781-8. doi: 10.1161/01.hyp.26.5.781.
In previous studies investigators found that conditioned hypoventilatory breathing potentiated a sodium-sensitive form of hypertension in dogs that was not mediated by sympathetic nervous system arousal. Our study investigated effects of 30 minutes of voluntary hypoventilation, maintained by a respiratory gas monitor and feedback procedure, in 16 normotensive humans of both sexes on (1) plasma concentrations of endogenous digitalis-like factors (ouabain-like and marinobufagenin-like immunoreactivity), (2) activity of erythrocyte Na+, K+ -ATPase, (3) inhibitory activity of plasma Na+, K+ -ATPase, and (4) blood pressure. Increased end tidal PCO2 (41 +/- 0.78 mm Hg versus 37.6 +/- 1.03 mm Hg) was associated with (1) an increase in plasma marinobufagenin-like immunoreactivity (1.23 +/- 0.47 versus 4.96 +/- 1.19 nmol/L), (2) an inhibition of Na+, K+ -ATPase in red blood cells (3.68 +/- 0.22 versus 2.15 +/- 0.25 mmol Pi/mL-1/h-1; P < .01), (3) increase in plasma Na+, K+ -ATPase inhibitory activity (34.9 +/- 4.0% versus 48.8 +/- 2.1%, P < .02), and (4) increases in systolic (112.4 +/- 2.6 versus 107.6 +/- 1.8 mm Hg) and diastolic (73.5 +/- 2.1 versus 68.8 +/- 2.1 mm Hg) blood pressures. Plasma levels of ouabain-like immunoreactivity did not increase significantly. Incubation of erythrocytes obtained during hypoventilation with antidigoxin antibody restored the Na+, K+ -ATPase activity (3.99 +/- 0.34 mmol Pi/mL-1/h-1). Cessation of hypoventilation was associated with decreases in diastolic blood pressure (70.5 +/- 2.2 mm Hg) and restoration of Na+, K+ -ATPase activity in erythrocytes (2.99 +/- 0.43 mmol Pi/mL-1/h1).(ABSTRACT TRUNCATED AT 250 WORDS)
在先前的研究中，研究人员发现，条件性低通气呼吸会增强犬类中一种对钠敏感的高血压形式，这种高血压并非由交感神经系统兴奋介导。我们的研究调查了在呼吸气体监测器和反馈程序维持下，30分钟的自主低通气对16名血压正常的男女的影响，包括：（1）内源性洋地黄样因子（哇巴因样和海蟾蜍毒配基样免疫反应性）的血浆浓度；（2）红细胞钠钾ATP酶的活性；（3）血浆钠钾ATP酶的抑制活性；（4）血压。呼气末二氧化碳分压升高（从37.6±1.03毫米汞柱升至41±0.78毫米汞柱）与以下情况相关：（1）血浆海蟾蜍毒配基样免疫反应性增加（从1.23±0.47纳摩尔/升升至4.96±1.19纳摩尔/升）；（2）红细胞中钠钾ATP酶受到抑制（从3.68±0.22毫摩尔无机磷/毫升-1/小时降至2.15±0.25毫摩尔无机磷/毫升-1/小时；P<.01）；（3）血浆钠钾ATP酶抑制活性增加（从34.9±4.0%升至48.8±2.1%，P<.02）；（4）收缩压（从107.6±1.8毫米汞柱升至112.4±2.6毫米汞柱）和舒张压（从68.8±2.1毫米汞柱升至73.5±2.1毫米汞柱）升高。血浆中哇巴因样免疫反应性水平未显著增加。用抗地高辛抗体孵育低通气期间获取的红细胞可恢复钠钾ATP酶活性（3.99±0.34毫摩尔无机磷/毫升-1/小时）。停止低通气与舒张压降低（70.5±2.2毫米汞柱）以及红细胞中钠钾ATP酶活性恢复（2.99±0.43毫摩尔无机磷/毫升-1/小时）相关。（摘要截选至250词）
