人类对恶性疟原虫裂殖子表面蛋白2的抗体反应具有血清群特异性，且主要为免疫球蛋白G3亚类。
Human antibody response to Plasmodium falciparum merozoite surface protein 2 is serogroup specific and predominantly of the immunoglobulin G3 subclass.
作者信息
Taylor R R, Smith D B, Robinson V J, McBride J S, Riley E M
机构信息
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Scotland.
出版信息
Infect Immun. 1995 Nov;63(11):4382-8. doi: 10.1128/iai.63.11.4382-4388.1995.
Abstract
MSP2 is a merozoite surface protein of Plasmodium falciparum and, as such, is a potential component of a malaria vaccine. In this study, we have used a panel of recombinant MSP2 antigens in enzyme-linked immunosorbent assays to investigate the recognition of MSP2 by antibodies from malaria-immune human serum. These recombinant antigens include full-length proteins of serogroups A and B and fragments representing the conserved, group-specific, or repeat regions of each serogroup. Ninety-five percent of the serum samples tested contained MSP2-specific antibodies: 81% of serum samples tested responded to serogroup A, and 86% responded to serogroup B. The antibody response is directed almost exclusively towards dimorphic and polymorphic regions of MSP2; the conserved regions are rarely recognized, and antibodies to serogroups A and B do not cross-react. Interestingly, the antibody response is predominately of the cytophilic and complement-fixing subclass immunoglobulin G3.
摘要
MSP2是恶性疟原虫的裂殖子表面蛋白，因此是疟疾疫苗的潜在成分。在本研究中，我们使用一组重组MSP2抗原进行酶联免疫吸附测定，以研究疟疾免疫人血清中的抗体对MSP2的识别。这些重组抗原包括血清群A和B的全长蛋白以及代表每个血清群保守、群特异性或重复区域的片段。95%的检测血清样本含有MSP2特异性抗体：81%的检测血清样本对血清群A有反应，86%对血清群B有反应。抗体反应几乎完全针对MSP2的二态性和多态性区域；保守区域很少被识别，血清群A和B的抗体不发生交叉反应。有趣的是，抗体反应主要是嗜细胞性和补体固定亚类免疫球蛋白G3。
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Human antibody response to Plasmodium falciparum merozoite surface protein 2 is serogroup specific and predominantly of the immunoglobulin G3 subclass.人类对恶性疟原虫裂殖子表面蛋白2的抗体反应具有血清群特异性，且主要为免疫球蛋白G3亚类。
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