人白细胞介素10诱导初始表面免疫球蛋白D+(sIgD+)B细胞分泌IgG1和IgG3。
Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.
作者信息
Brière F, Servet-Delprat C, Bridon J M, Saint-Remy J M, Banchereau J
机构信息
Laboratory for Immunological Research, Schering-Plough, Dardilly, France.
出版信息
J Exp Med. 1994 Feb 1;179(2):757-62. doi: 10.1084/jem.179.2.757.
Abstract
During antigen-induced immune responses, human B cells switch isotype from immunoglobulin M (IgM)-IgD to IgG1-4, IgA1-2, or IgE. In the human, no cytokines have yet been demonstrated to act as switch factors for IgG1, IgG2, and IgG3. In this paper, we report that in response to interleukin 10 (IL-10), anti-CD40 activated tonsillar surface IgD+ (sIgD+) B cells are induced to secrete large amounts of IgM, IgG1, and IgG3 but neither IgG2 nor IgG4. Cord blood purified B cells and lymphocytes from Hyper-IgM patients also produced IgG1 and IgG3 after culture with anti-CD40 and IL-10. In contrast, sIgD- isotype-committed B cells produce IgG1, IgG2, and IgG3 when activated through CD40 in the presence of IL-10. Thus, in addition to its growth-promoting and differentiating activities on human B cells, IL-10 may represent a switch factor for IgG1 and IgG3.
摘要
在抗原诱导的免疫反应过程中，人类B细胞的免疫球蛋白同种型从免疫球蛋白M（IgM）-IgD转换为IgG1-4、IgA1-2或IgE。在人类中，尚未证实有细胞因子可作为IgG1、IgG2和IgG3的转换因子。在本文中，我们报道，在白细胞介素10（IL-10）作用下，抗CD40激活的扁桃体表面IgD+（sIgD+）B细胞被诱导分泌大量的IgM、IgG1和IgG3，但不分泌IgG2和IgG4。脐血纯化的B细胞以及来自高IgM患者的淋巴细胞在与抗CD40和IL-10共同培养后也产生IgG1和IgG3。相比之下，sIgD-同种型定向的B细胞在IL-10存在的情况下通过CD40激活时会产生IgG1、IgG2和IgG3。因此，除了其对人类B细胞的促生长和分化活性外，IL-10可能代表IgG1和IgG3的转换因子。
相似文献
1
Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.人白细胞介素10诱导初始表面免疫球蛋白D+(sIgD+)B细胞分泌IgG1和IgG3。
J Exp Med. 1994 Feb 1;179(2):757-62. doi: 10.1084/jem.179.2.757.
2
3
IL-4 and transforming growth factor-beta suppress human immunoglobulin secretion in vitro by surface IgD- B cells.白细胞介素-4和转化生长因子-β在体外可抑制表面免疫球蛋白D阴性B细胞分泌人免疫球蛋白。
Clin Exp Immunol. 1992 Aug;89(2):261-8. doi: 10.1111/j.1365-2249.1992.tb06942.x.
4
Deoxyspergualin preferentially inhibits the growth and maturation of anti-CD40-activated surface IgD+ B lymphocytes.去氧精胍菌素优先抑制抗CD40激活的表面IgD+B淋巴细胞的生长和成熟。
Clin Exp Immunol. 1998 Jun;112(3):495-500. doi: 10.1046/j.1365-2249.1998.00602.x.
5
Human immunoglobulin class and IgG subclass regulation: dual action of interleukin-4.人类免疫球蛋白类别及IgG亚类调节：白细胞介素-4的双重作用
Eur J Immunol. 1993 Sep;23(9):2250-6. doi: 10.1002/eji.1830230930.
6
Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.白细胞介素10与转化生长因子β协同作用，诱导抗CD40激活的人初始B细胞分泌免疫球蛋白A。
J Exp Med. 1992 Mar 1;175(3):671-82. doi: 10.1084/jem.175.3.671.
7
Interleukin 8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells.白细胞介素8（IL-8）可选择性抑制白细胞介素4在人B细胞中诱导产生免疫球蛋白E。
J Exp Med. 1992 Oct 1;176(4):1227-31. doi: 10.1084/jem.176.4.1227.
8
IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4.白细胞介素-21诱导人初始B细胞向IgG和IgA的同种型转换受白细胞介素-4的差异调节。
J Immunol. 2008 Aug 1;181(3):1767-79. doi: 10.4049/jimmunol.181.3.1767.
9
Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes.白细胞介素-10诱导人CD40激活的初始B淋巴细胞中的免疫球蛋白G同种型转换重组。
J Exp Med. 1996 Mar 1;183(3):937-47. doi: 10.1084/jem.183.3.937.
10
Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2.人树突状细胞使CD40激活的初始B细胞的同种型转换偏向IgA1和IgA2。
J Exp Med. 1997 Jun 2;185(11):1909-18. doi: 10.1084/jem.185.11.1909.
引用本文的文献
1
Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients.嵌合抗HLA抗体受体工程化人调节性T细胞可抑制预致敏移植受者的同种抗原特异性B细胞。
Front Immunol. 2025 Aug 15;16:1601385. doi: 10.3389/fimmu.2025.1601385. eCollection 2025.
2
Characterization of class-switched B cells in chickens.鸡中类别转换B细胞的特征分析。
Front Immunol. 2024 Nov 21;15:1484288. doi: 10.3389/fimmu.2024.1484288. eCollection 2024.
3
Expanding Human Breg for Cellular Therapy in Transplantation: Time for Translation.拓展人类调节性B细胞用于移植中的细胞治疗：转化时机已至。
Transplantation. 2025 Jun 1;109(6):926-937. doi: 10.1097/TP.0000000000005243. Epub 2024 Oct 23.
4
Interleukin-10 Deficiency Impacts on TNF-Induced NFκB Regulated Responses In Vivo.白细胞介素-10缺乏对体内肿瘤坏死因子诱导的核因子κB调节反应的影响。
Biology (Basel). 2022 Sep 20;11(10):1377. doi: 10.3390/biology11101377.
5
Adipokines, and not vitamin D, associate with antibody immune responses following dual BNT162b2 vaccination within individuals younger than 60 years.脂联素，而不是维生素 D，与 60 岁以下个体接受双价 BNT162b2 疫苗接种后的抗体免疫反应相关。
Front Immunol. 2022 Sep 2;13:1000006. doi: 10.3389/fimmu.2022.1000006. eCollection 2022.
6
IL-10 revisited in systemic lupus erythematosus.重新审视系统性红斑狼疮中的白细胞介素-10。
Front Immunol. 2022 Aug 1;13:970906. doi: 10.3389/fimmu.2022.970906. eCollection 2022.
7
Peripheral B-cell dysregulation is associated with relapse after long-term quiescence in patients with multiple sclerosis.外周 B 细胞失调与多发性硬化症患者长期静止后复发有关。
Immunol Cell Biol. 2022 Jul;100(6):453-467. doi: 10.1111/imcb.12552. Epub 2022 May 12.
8
Genome Instability in Multiple Myeloma: Facts and Factors.多发性骨髓瘤中的基因组不稳定：事实与因素
Cancers (Basel). 2021 Nov 26;13(23):5949. doi: 10.3390/cancers13235949.
9
IgG3 and IL10 are effective biomarkers for monitoring therapeutic effectiveness in Post Kala-Azar Dermal Leishmaniasis.IgG3 和 IL10 是监测 Post Kala-Azar Dermal Leishmaniasis 治疗效果的有效生物标志物。
PLoS Negl Trop Dis. 2021 Nov 10;15(11):e0009906. doi: 10.1371/journal.pntd.0009906. eCollection 2021 Nov.
10
IgG Subclass Analysis in Patients with Chagas Disease 4 Years After Benznidazole Treatment.恰加斯病患者贝那唑嗪治疗 4 年后 IgG 亚类分析。
Acta Parasitol. 2021 Dec;66(4):1499-1509. doi: 10.1007/s11686-021-00430-3. Epub 2021 Jun 11.
本文引用的文献
1
Immune response in mice that lack the interferon-gamma receptor.缺乏干扰素-γ受体的小鼠的免疫反应。
Science. 1993 Mar 19;259(5102):1742-5. doi: 10.1126/science.8456301.
2
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.白细胞介素13可诱导人B细胞在不依赖白细胞介素4的情况下合成IgG4和IgE，并表达CD23。
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3730-4. doi: 10.1073/pnas.90.8.3730.
3
4
CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome.导致X连锁高IgM综合征的CD40配体基因缺陷。
Science. 1993 Feb 12;259(5097):990-3. doi: 10.1126/science.7679801.
5
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM.T细胞CD40配体的表达缺陷导致X连锁高IgM免疫缺陷。
Nature. 1993 Feb 11;361(6412):539-41. doi: 10.1038/361539a0.
6
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.X连锁高IgM综合征患者活化T细胞中的CD40配体gp39存在缺陷。
Cell. 1993 Jan 29;72(2):291-300. doi: 10.1016/0092-8674(93)90668-g.
7
T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.T细胞衍生的B细胞分化因子。对小鼠B细胞同种型转换的影响。
J Exp Med. 1982 Mar 1;155(3):734-48. doi: 10.1084/jem.155.3.734.
8
IgG subclasses in bacterial infections.细菌感染中的IgG亚类
Monogr Allergy. 1986;19:122-33.
9
10
IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.干扰素-γ调节体内体液免疫反应期间分泌的Ig的同种型。
J Immunol. 1988 Feb 15;140(4):1022-7.
Zotero 插件