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针对人γ链上决定簇的单克隆抗体（McAbs）：表现出亚类限制或亚类特异性的抗体特性。

Monoclonal antibodies (McAbs) to determinants on human gamma chains: properties of antibodies showing subclass restriction or subclass specificity.

作者信息

Lowe J, Bird P, Hardie D, Jefferis R, Ling N R

出版信息

Immunology. 1982 Oct;47(2):329-36.

PMID:6180976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555448/
Abstract

Thirteen monoclonal antibodies (McAbs) showing subclass-specific and subclass-restricted reactivity to human IgG have been produced by the hybridoma technique. Their specificity has been defined by passive haemagglutination (HA) and haemagglutination-inhibition (HAI) assays using a large panel pf purified IgG paraproteins of known subclass. Their use in assaying human IgG subclasses in radial immunodiffusion (RID) and in purifying human subclasses by both positive and negative immunoabsorption chromatography is illustrated.

摘要

通过杂交瘤技术制备了13种对人IgG具有亚类特异性和亚类限制性反应性的单克隆抗体（McAbs）。利用大量已知亚类的纯化IgG副蛋白，通过被动血凝（HA）和血凝抑制（HAI）试验确定了它们的特异性。文中展示了它们在放射免疫扩散（RID）中检测人IgG亚类以及通过正、负免疫吸附色谱法纯化人IgG亚类中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96aa/1555448/713e73773b29/immunology00223-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96aa/1555448/713e73773b29/immunology00223-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96aa/1555448/713e73773b29/immunology00223-0111-a.jpg

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