与巴西紫癜热相关的埃及生物群流感嗜血杆菌产生的免疫球蛋白A1蛋白酶的独特抗原性和遗传特性。
Distinct antigenic and genetic properties of the immunoglobulin A1 protease produced by Haemophilus influenzae biogroup aegyptius associated with Brazilian purpuric fever in Brazil.
作者信息
Lomholt H, Kilian M
机构信息
Department of Medical Microbiology and Immunology, University of Aarhus, Denmark.
出版信息
Infect Immun. 1995 Nov;63(11):4389-94. doi: 10.1128/iai.63.11.4389-4394.1995.
Abstract
All examined Haemophilus influenzae biogroup aegyptius isolates of the clone associated with Brazilian purpuric fever (the BPF clone) produced type 2 immunoglobulin A1 (IgA1) proteases encoded by identical iga genes that were distinct from the iga genes of other Brazilian H. influenzae biogroup aegyptius isolates. A partial nucleotide sequence analysis revealed close similarities to the iga genes of H. influenzae serotype c and one noncapsular H. influenzae biotype III strain isolated from a case of conjunctivitis in Tunisia, suggesting an evolutionary relationship. Epitopes recognized by neutralizing antibodies differed for the IgA1 proteases of the BPF clone and of other H. influenzae strains, including Brazilian H. influenzae biogroup aegyptius isolates from patients with noninvasive conjunctivitis. The low probability of developing cross-reacting neutralizing antibodies to the IgA1 protease of the BPF clone may contribute to the pathogenic potential of this virulent phenotype in Brazil.
摘要
所有检测的与巴西紫癜热相关克隆（BPF克隆）的埃及生物群流感嗜血杆菌分离株都产生由相同iga基因编码的2型免疫球蛋白A1（IgA1）蛋白酶，这些基因与其他巴西埃及生物群流感嗜血杆菌分离株的iga基因不同。部分核苷酸序列分析显示，其与c型流感嗜血杆菌以及从突尼斯一例结膜炎病例中分离出的一株非荚膜III型流感嗜血杆菌生物型的iga基因有密切相似性，提示存在进化关系。BPF克隆和其他流感嗜血杆菌菌株（包括来自非侵袭性结膜炎患者的巴西埃及生物群流感嗜血杆菌分离株）的IgA1蛋白酶被中和抗体识别的表位不同。针对BPF克隆的IgA1蛋白酶产生交叉反应中和抗体的可能性较低，这可能有助于这种强毒表型在巴西的致病潜力。
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