新南威尔士州肾癌的风险因素。IV.职业。
Risk factors for kidney cancer in New South Wales. IV. Occupation.
作者信息
McCredie M, Stewart J H
机构信息
NSW Central Cancer Registry and Cancer Epidemiology Research Unit, NSW Cancer Council, Australia.
出版信息
Br J Ind Med. 1993 Apr;50(4):349-54. doi: 10.1136/oem.50.4.349.
In a population based case-control study of kidney cancer in New South Wales, data from structured interviews with 489 cases of renal cell cancer (RCC), 147 cases of renal pelvic cancer (CaRP), and 523 controls from the electoral roles were obtained about employment in certain industries or occupations, and exposure to particular chemicals chosen because of suspected associations with kidney cancer. A low level of education increased the risk for CaRP but not RCC. After adjustment for known risk factors, exposure to asbestos significantly increased the risk for RCC (relative risk (RR) = 1.62; 95% confidence interval (95% CI) 1.04-2.53). Working in the dry cleaning industry had a stronger link with CaRP (RR = 4.68; 95% CI 1.32-16.56) than with RCC (RR = 2.49; 95% CI 0.97-6.35). Working in the iron and steel industry doubled the risk for CaRP (RR = 2.13; 95% CI 1.04-4.39) whereas employment in the petroleum refining industry had a non-significant association with CaRP (RR = 2.60; 95% CI 0.88-7.63) and none with RCC.
在一项基于新南威尔士州肾癌的人群病例对照研究中，通过对489例肾细胞癌（RCC）、147例肾盂癌（CaRP）患者以及523名来自选民名单的对照者进行结构化访谈，获取了有关某些行业或职业的就业情况，以及因怀疑与肾癌有关联而选定的特定化学物质暴露情况的数据。低教育水平会增加患肾盂癌的风险，但不会增加患肾细胞癌的风险。在对已知风险因素进行调整后，接触石棉会显著增加患肾细胞癌的风险（相对风险（RR）= 1.62；95%置信区间（95%CI）为1.04 - 2.53）。从事干洗行业与肾盂癌的关联（RR = 4.68；95%CI为1.32 - 16.56）比与肾细胞癌的关联（RR = 2.49；95%CI为0.97 - 6.35）更强。在钢铁行业工作会使患肾盂癌的风险加倍（RR = 2.13；95%CI为1.04 - 4.39），而在石油精炼行业就业与肾盂癌有不显著的关联（RR = 2.60；95%CI为0.88 - 7.63），与肾细胞癌无关联。
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