Time courses of cardiac output and oxygen uptake following stepwise increases in exercise intensity.

The adjustment of pulmonary oxygen uptake (VO2) following a step increase in work rate has been characterized as consisting of an early "cardiodynamic" component with unchanged mixed-venous O2-content ("phase 1") and a subsequent "metabolic" component ("phase 2") starting when venous blood from the muscle arrives at the lungs. The aim of the present study was to investigate whether the onset of phase 2 actually indicates the arrival of blood influenced by the altered muscle metabolism. Parallel measurements of cardiac output (Doppler technique) and VO2 (breath-by-breath measurements at the mouth) were performed in eight subjects during step increases in exercise intensity (from a 20 W baseline to either 80 W, 120 W, 160 W or 200 W). To vary the absolute cardiac output values for given muscle VO2 the subjects exercised both in upright and supine position. Individual time-courses of the arterio-venous O2 difference (a-v delta O2) were computed from cardiac output and VO2 data. Independent of body position two clear-cut phases of similar duration were seen both in VO2 and in the computed a-v delta O2. The duration of the first component with unchanged a-v delta O2 was about 20 s at the lowest step amplitudes (20-80 W and 20-120 W). It decreased to about 15 s for the 20-160 W and 20-200 W steps. At the lower exercise intensities the duration of phase 1 appears too long to be entirely due to the transit time of venous blood from the exercising muscles to the lungs.(ABSTRACT TRUNCATED AT 250 WORDS)