Wallgren F, Amberg G, Hickner R C, Ekelund U, Jorfeldt L, Henriksson J
Department of Mechanics, Royal Institute of Technology, Stockholm, Sweden.
J Appl Physiol (1985). 1995 Aug;79(2):648-59. doi: 10.1152/jappl.1995.79.2.648.
A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoretically calculated results are compared with experiments, and for at least one of the two probe types used good agreement is achieved in a wide range of blood flow and perfusate flow rates. The main uncertainty factor in the theoretical calculations is the diffusivity of ethanol in muscle tissue, and the value for best agreement between theory and experiments has been used. Error estimates show that for a constant relative error in the outflow-to-inflow ratio of ethanol in the perfusate, low perfusate flow rates give better predictions of the blood flow.
本文对骨骼肌微透析乙醇技术进行了理论分析，并提出了一个控制乙醇从微透析探针向肌肉组织毛细血管转运的模型。该模型是在稳态假设下推导出来的，并得到了灌注液中乙醇流出与流入比率的解析解。将理论计算结果与实验进行了比较，对于所使用的两种探针类型中的至少一种，在广泛的血流和灌注液流速范围内取得了良好的一致性。理论计算中的主要不确定因素是乙醇在肌肉组织中的扩散系数，采用了理论与实验最佳吻合的值。误差估计表明，对于灌注液中乙醇流出与流入比率的恒定相对误差，低灌注液流速能更好地预测血流。
