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来自牛链球菌的两种磷酸糖磷酸酶的特性及其在诱导物排出中的潜在作用。

Properties of two sugar phosphate phosphatases from Streptococcus bovis and their potential involvement in inducer expulsion.

作者信息

Cook G M, Ye J J, Russell J B, Saier M H

机构信息

Section of Microbiology, Cornell University, Ithaca, NY 14853, USA.

出版信息

J Bacteriol. 1995 Dec;177(23):7007-9. doi: 10.1128/jb.177.23.7007-7009.1995.

DOI:10.1128/jb.177.23.7007-7009.1995
PMID:7592500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177575/
Abstract

Streptococcus bovis possesses two sugar phosphate phosphatases (Pases). Pase I is a soluble enzyme that is inhibited by the membrane fractions from lactose-grown cells and is insensitive to activation by S46D HPr, an analog of HPr(ser-P) of the sugar phosphotransferase system. Pase II is a membrane-associated enzyme that can be activated 10-fold by S46D HPr, and it appears to play a role in inducer expulsion.

摘要

牛链球菌拥有两种磷酸糖磷酸酶（Pases）。磷酸酶I是一种可溶性酶，受乳糖生长细胞的膜组分抑制，对糖磷酸转移酶系统中HPr(ser-P)的类似物S46D HPr的激活不敏感。磷酸酶II是一种与膜相关的酶，可被S46D HPr激活10倍，它似乎在诱导物排出中起作用。

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2
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本文引用的文献

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Inhibition of the phosphoenolpyruvate:lactose phosphotransferase system and activation of a cytoplasmic sugar-phosphate phosphatase in Lactococcus lactis by ATP-dependent metabolite-activated phosphorylation of serine 46 in the phosphocarrier protein HPr.通过磷酸载体蛋白HPr中丝氨酸46的ATP依赖性代谢物激活磷酸化作用，抑制乳酸乳球菌中的磷酸烯醇丙酮酸：乳糖磷酸转移酶系统并激活细胞质糖磷酸磷酸酶。
J Biol Chem. 1994 Apr 22;269(16):11837-44.
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Purification and characterization of a small membrane-associated sugar phosphate phosphatase that is allosterically activated by HPr(Ser(P)) of the phosphotransferase system in Lactococcus lactis.乳酸乳球菌中一种小的膜相关糖磷酸磷酸酶的纯化与特性分析，该酶被磷酸转移酶系统的HPr(Ser(P))变构激活。
J Biol Chem. 1995 Jul 14;270(28):16740-4. doi: 10.1074/jbc.270.28.16740.
6
Regulation of the lactose phosphotransferase system of Streptococcus bovis by glucose: independence of inducer exclusion and expulsion mechanisms.葡萄糖对牛链球菌乳糖磷酸转移酶系统的调控：诱导物排除和排出机制的独立性
Microbiology (Reading). 1995 Sep;141 ( Pt 9):2261-9. doi: 10.1099/13500872-141-9-2261.
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Properties of ATP-dependent protein kinase from Streptococcus pyogenes that phosphorylates a seryl residue in HPr, a phosphocarrier protein of the phosphotransferase system.化脓性链球菌中能使磷酸转移酶系统的磷酸载体蛋白HPr中的一个丝氨酸残基磷酸化的ATP依赖性蛋白激酶的特性。
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