Spenney J G, Tobin M M, Mihas A A, Gibson R G, Hirschowitz B I, Johnson B J, Tauxe W N
Gastroenterology. 1979 Feb;76(2):272-8.
An 125I- or 131I-labeled bile salt derivative, cholylglycyliodohistamine, has been synthesized and purified. The bile salt derivative is rapidly cleared from the circulation when injected intravenously into rats and rabbits. Ten minutes after injection, approximately 50% of the recovered bile salt derivative was in the jejunum and ileum, and 36% was found in the liver. Sixty minutes after injection, 99% of the recovered radioactivity was found in the luminal gastrointestinal tract. The isotope was cleared from the circulation of rabbits with a t1/2 of approximately 2 min. Hepatic scintigraphy using rabbits demonstrated rapid uptake by the liver and excretion into the intestine. Quantitative analysis of scintigraphy showed an uptake rate of 14%/min and a subsequent excretory rate of 4.6/min.
一种125I或131I标记的胆盐衍生物——胆酰甘氨碘组胺已被合成并纯化。当静脉注射到大鼠和兔子体内时，这种胆盐衍生物会迅速从循环系统中清除。注射后10分钟，回收的胆盐衍生物约50%位于空肠和回肠，36%在肝脏中被发现。注射后60分钟，99%回收的放射性物质在胃肠道腔内被发现。该同位素从兔子的循环系统中清除的半衰期约为2分钟。对兔子进行的肝脏闪烁扫描显示肝脏迅速摄取并排泄到肠道。闪烁扫描的定量分析显示摄取率为14%/分钟，随后的排泄率为4.6/分钟。
