Joshi M D, Suh J K, Marui T, Woo S L
Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania 15213, USA.
J Biomed Mater Res. 1995 Jul;29(7):823-8. doi: 10.1002/jbm.820290706.
Various animal models have been used to investigate the normal and reparative properties of the knee meniscus. Yet, only limited data on meniscal biomechanical properties of various animals are available. It was therefore the objective of this study to compare measurements of meniscal biomechanical properties between six species: human, bovine, monkey, canine, sheep, and porcine. Uniaxial confined compression tests were conducted on 1-mm-thick, 4-mm-diameter meniscal discs, and the viscoelastic creep deformation was obtained. Two biomechanical parameters, the aggregate modulus (HA) and permeability (K), were found by implementing the linear biphasic theory and a newly developed nonlinear regression scheme. A one-way analysis of variance was conducted along with Student-Newman-Keuls comparison tests to assess the differences in these parameters among the species. Sheep menisci exhibited HA and K values most similar to human menisci. The water content of each specimen was also measured and correlated significantly with K. The interspecies variations found in material properties of the knee meniscus indicate the need for caution in extrapolating data on the biomechanical behavior of the human meniscus from animal models.
已经使用了各种动物模型来研究膝关节半月板的正常和修复特性。然而，关于各种动物半月板生物力学特性的数据有限。因此，本研究的目的是比较六种物种（人类、牛、猴子、犬、绵羊和猪）之间半月板生物力学特性的测量结果。对1毫米厚、4毫米直径的半月板圆盘进行单轴受限压缩试验，并获得粘弹性蠕变变形。通过应用线性双相理论和新开发的非线性回归方案，发现了两个生物力学参数，即聚集模量（HA）和渗透率（K）。进行了单因素方差分析以及Student-Newman-Keuls比较试验，以评估这些参数在物种之间的差异。绵羊半月板的HA和K值与人类半月板最相似。还测量了每个标本的含水量，并且含水量与K显著相关。在膝关节半月板材料特性中发现的种间差异表明，在从动物模型推断人类半月板生物力学行为数据时需要谨慎。
