Epidermal cytokines in allergic contact dermatitis.

The understanding of cutaneous immunology has grown significantly during the past decade, particularly regarding the immune function of keratinocytes. Keratinocytes play a major role in immune and inflammatory reactions, mainly through synthesis and release of cytokines. The cytokine network in the skin is an important contributor to normal homeostasis and to the pathogenesis of cutaneous disease. Although cytokine dysregulation has been implicated in the pathogenesis of many cutaneous diseases, allergic contact dermatitis is one that has been the most extensively studied. The aim of this article is to provide a comprehensive current review of the mechanisms of allergic contact dermatitis with particular emphasis on the role of epidermal cytokines.