Lewis M G, Organisciak D T
Invest Ophthalmol Vis Sci. 1979 Jan;18(1):95-9.
The influence of light environment on rhodopsin concentration per eye was determined in littermate pigmented and nonpigmented C57BL/6J-pallid gene mice reared under cyclic light or continuous dark environments. Attempts to exacerbate a congenital manganese deficiency in pallid strain mice included dietary deprivation and supplementation with manganese and exposure to intense light followed by the determination of rhodopsin recovery rates in darkness. Homozygous pallid mice (pa/pa) reared in cyclic light had rhodopsin levels which were significantly lower than heterozygous (+/pa) or homozygous (+/+) black control mice. Dark-rearing resulted in a significant increase in rhodopsin per eye in pallid strain mice and equivalent levels in adult mice, but young pallid strain mice did not achieve the same rhodopsin concentration as young +/+ mice. Although dietary manganese deprivation or supplementation did not significantly alter rhodopsin levels among pallid mice, the deficient diet resulted in lower rhodopsin per eye in the young +/+ control animals. The recovery of rhodopsin in darkness following intense light exposure was equal and complete within 24 hr for most genotypes. However, recovery by pallid mice after 24 hr was significantly lower than by pigmented or albino genotypes.
在周期性光照或持续黑暗环境中饲养的同窝有色素和无色素的C57BL/6J-苍白基因小鼠中，测定了光照环境对每只眼睛视紫红质浓度的影响。为加剧苍白品系小鼠先天性锰缺乏所做的尝试包括饮食剥夺、补充锰以及暴露于强光下，随后测定黑暗中视紫红质的恢复率。在周期性光照下饲养的纯合苍白小鼠（pa/pa）的视紫红质水平显著低于杂合子（+/pa）或纯合子（+/+）黑色对照小鼠。黑暗饲养导致苍白品系小鼠每只眼睛的视紫红质显著增加，成年小鼠的视紫红质水平相当，但年幼的苍白品系小鼠没有达到与年幼的+/+小鼠相同的视紫红质浓度。尽管饮食中锰的剥夺或补充并没有显著改变苍白小鼠的视紫红质水平，但缺乏锰的饮食导致年幼的+/+对照动物每只眼睛的视紫红质较低。对于大多数基因型，强光照射后24小时内，黑暗中视紫红质的恢复是相等且完全的。然而，24小时后苍白小鼠的恢复明显低于有色素或白化基因型的小鼠。
