Murakami M, Saita H, Takahashi Y, Kusaka S, Asagoe K, Dekigai H, Matsumoto M, Seki M, Mizuno M, Maeda S
Department of Geriatric Medicine, Kyoto University, Japan.
J Clin Gastroenterol. 1995;20 Suppl 2:S79-82. doi: 10.1097/00004836-199506002-00021.
We studied the effects of lansoprazole on ulcer healing and Helicobacter pylori infection in elderly patients with peptic ulcers. In a group of 24 patients with gastric ulcers, the H. pylori infection rate was 100%. In the course of gastric ulcer healing with famotidine or lansoprazole alone, the H. pylori infection showed no signs of decline. The ulcer healing rates after 8 weeks were similar between the H2-receptor antagonist famotidine (73%), and the proton pump inhibitor lansoprazole (82%). When eradication of H. pylori infection was attempted by concomitant administration of lansoprazole and amoxicillin 500 mg b.i.d. for 2 weeks, the eradication rate was 33% in the group given lansoprazole 30 mg q.d. plus ampicillin 500 mg b.i.d., whereas it was 77% in the group given lansoprazole 30 mg b.i.d. plus ampicillin 500 mg b.i.d. Lansoprazole is considered to be a useful agent for the treatment of patients with peptic ulcers and H. pylori infection and its effectiveness in H. pylori eradication is improved by b.i.d. administration along with ampicillin.
我们研究了兰索拉唑对老年消化性溃疡患者溃疡愈合及幽门螺杆菌感染的影响。在一组24例胃溃疡患者中，幽门螺杆菌感染率为100%。在用法莫替丁或单独使用兰索拉唑治疗胃溃疡的过程中，幽门螺杆菌感染未见下降迹象。8周后，H2受体拮抗剂法莫替丁组（73%）和质子泵抑制剂兰索拉唑组（82%）的溃疡愈合率相似。当尝试通过联合使用兰索拉唑和阿莫西林（500毫克，每日两次，共2周）根除幽门螺杆菌感染时，兰索拉唑30毫克每日一次加阿莫西林500毫克每日两次组的根除率为33%，而兰索拉唑30毫克每日两次加阿莫西林500毫克每日两次组的根除率为77%。兰索拉唑被认为是治疗消化性溃疡和幽门螺杆菌感染患者的有效药物，与阿莫西林每日两次联合给药可提高其根除幽门螺杆菌的有效性。
