Hashimoto M, Hoshihara Y, Yamamoto T, Tanaka T, Kimura T, Iguchi D, Sugawara K, Fukuchi S, Takemoto T
Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
J Clin Gastroenterol. 1995;20 Suppl 2:S59-61. doi: 10.1097/00004836-199506002-00016.
When healing of gastric ulcers is observed using an electronic endoscope with a magnifying function, five types of regenerated mucosa can be distinguished. The membranous type appears first at the ulcer margin and is followed by the spindle-shaped and palisade-shaped regenerated mucosae that plays an important role in ulcer healing. These two types change into the cobblestone-shaped and the basically normal structure, which have an important relation to the maturity of ulcer healing. In observation of gastric ulcer healing in 10 patients who received lansoprazole 30 mg (L group) or in 12 patients who received famotidine 20 mg b.i.d. (F group), the spindle- and palisade-shaped mucosae were significantly more developed in the L group than in the F group after 4 weeks (p < 0.05). On the other hand, after 8 weeks, the development of these two types of mucosa was less extensive in the L group than in the F group, because these two types had changed into cobblestone-shaped and basically normal structure in the L group. In conclusion, treatment with lansoprazole resulted in more rapid ulcer healing and maturation of regenerated mucosa than did treatment with famotidine in this study.
使用具有放大功能的电子内窥镜观察胃溃疡愈合情况时，可区分出五种类型的再生黏膜。膜状型首先出现在溃疡边缘，随后是纺锤形和栅栏状再生黏膜，它们在溃疡愈合中起重要作用。这两种类型会转变为鹅卵石状和基本正常的结构，这与溃疡愈合的成熟度有重要关系。在观察10例接受30毫克兰索拉唑治疗的患者（L组）和12例接受法莫替丁20毫克每日两次治疗的患者（F组）的胃溃疡愈合情况时，4周后L组的纺锤形和栅栏状黏膜比F组更明显地发育（p < 0.05）。另一方面，8周后，L组这两种类型黏膜的发育程度比F组低，因为L组中这两种类型已转变为鹅卵石状和基本正常的结构。总之，在本研究中，与法莫替丁治疗相比，兰索拉唑治疗使溃疡愈合和再生黏膜成熟更快。
