Noriega F R, Liao F M, Formal S B, Fasano A, Levine M M
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA.
J Infect Dis. 1995 Nov;172(5):1408-10. doi: 10.1093/infdis/172.5.1408.
Shigella enterotoxin 1 (ShET1) is a novel, iron-dependent, toxin encoded by chromosomal genes (set1). To determine the prevalence of this enterotoxin, 172 Shigella clinical isolates (and 10 enteroinvasive Escherichia coli [EIEC]) from distant areas worldwide, representing all 4 groups and 45 serotypes of Shigella, were screened for set1 by DNA colony hybridization and polymerase chain reaction amplification. set1 was present in all 22 Shigella flexneri 2a strains tested but was rare in isolates of other Shigella serotypes (3.3%, 5/150) and not found in EIEC (0/10). That ShET1 is found almost exclusively in S. flexneri 2a may help explain the epidemiologic predominance of this serotype in the developing world.
志贺氏菌肠毒素1（ShET1）是一种由染色体基因（set1）编码的新型铁依赖性毒素。为了确定这种肠毒素的流行情况，通过DNA菌落杂交和聚合酶链反应扩增，对来自世界各地偏远地区的172株志贺氏菌临床分离株（以及10株侵袭性大肠杆菌[EIEC]）进行了set1筛查，这些分离株代表了志贺氏菌的所有4个群和45个血清型。在所有测试的22株福氏志贺氏菌2a菌株中均存在set1，但在其他志贺氏菌血清型的分离株中很少见（3.3%，5/150），在EIEC中未发现（0/10）。几乎仅在福氏志贺氏菌2a中发现ShET1，这可能有助于解释该血清型在发展中国家的流行病学优势。
