Arankalle V A, Chadha M S, Chobe L P, Nair R, Banerjee K
National Institute of Virology, Pune, India.
J Med Virol. 1995 Aug;46(4):358-63. doi: 10.1002/jmv.1890460411.
The aim of this study was to determine if rhesus monkeys infected with one isolate of hepatitis E virus (HEV) were immune to subsequent challenge with other isolates of the virus. Three epidemic and one sporadic Indian HEV isolates were employed in the study. The interval between primary inoculation and challenge varied from 1 year and 6 months to 2 years and 9 months. Evidence of HEV infection was ascertained by rise in serum alanine transaminase (ALT) levels and/or seroconversion to antibodies to HEV (anti-HEV), and the presence of HEV-RNA in the bile or faeces of the infected monkeys. No evidence for multiplication of virus in monkeys challenged with different HEV isolates was obtained. These results show that immunity generated by one isolate of HEV protects against different isolates of hepatitis E virus.
本研究的目的是确定感染一种戊型肝炎病毒（HEV）分离株的恒河猴是否对该病毒的其他分离株的后续攻击具有免疫力。研究中使用了三株流行的和一株散发的印度HEV分离株。初次接种与攻击之间的间隔从1年6个月到2年9个月不等。通过血清丙氨酸转氨酶（ALT）水平升高和/或抗HEV抗体血清转化以及感染猴子胆汁或粪便中存在HEV-RNA来确定HEV感染的证据。在用不同HEV分离株攻击的猴子中未获得病毒增殖的证据。这些结果表明，一种HEV分离株产生的免疫力可预防不同的戊型肝炎病毒分离株。
