Westarp M E, Ferrante P, Perron H, Bartmann P, Kornhuber H H
Department of Neurology, University of Ulm, Germany.
J Neurol Sci. 1995 May;129 Suppl:145-7. doi: 10.1016/0022-510x(95)00087-i.
Sporadic amyotrophic lateral sclerosis may be an aetiologically heterogenous disease. We confirmed elevated circulating IgG immune complexes, and altered IgG seroreactivities against human retroviral antigens (HIV-2 and HTLV immunoblots) in overlapping subgroups of patients. Together with preliminary findings of a positive polymerase chain reactivity for human T-lymphotropic virus (HTLV.tax/rex) in blood leukocytes of 5 out of 14 sALS patients, we interpret this as evidence for a retroviral involvement in this relentlessly progressive, often asymmetrically spreading neurodegeneration. The possibility of a secondary phenomenon seems unlikely, yet cannot be completely ruled out.
散发性肌萎缩侧索硬化症可能是一种病因异质性疾病。我们证实，在部分重叠的患者亚组中，循环IgG免疫复合物水平升高，且针对人类逆转录病毒抗原（HIV-2和HTLV免疫印迹）的IgG血清反应性发生改变。另外，在14例散发性肌萎缩侧索硬化症患者中，有5例患者血液白细胞中的人类嗜T淋巴细胞病毒（HTLV.tax/rex）聚合酶链反应呈阳性，基于这些初步发现，我们认为这是逆转录病毒参与这种持续进展、常呈不对称扩散的神经退行性变的证据。继发现象的可能性似乎不大，但也不能完全排除。
