Bergeron C
Centre for Research in Neurodegenerative Diseases, University of Toronto, Canada.
J Neurol Sci. 1995 May;129 Suppl:81-4. doi: 10.1016/0022-510x(95)00071-9.
The discovery of mutations in the Cu,Zn superoxide dismutase gene in familial ALS implicates oxidative stress in the pathogenesis of this disorder. Recent findings further suggest that oxidative stress may also be present in the more common sporadic form of the disease. The possible sources of oxidative stress in ALS are reviewed, and the participation of this disease mechanism to motorneuron death is discussed.
家族性肌萎缩侧索硬化症（ALS）中铜锌超氧化物歧化酶基因突变的发现表明氧化应激参与了该疾病的发病机制。最近的研究结果进一步表明，氧化应激也可能存在于更为常见的散发性ALS中。本文综述了ALS中氧化应激的可能来源，并讨论了这一疾病机制在运动神经元死亡中的作用。
