Moser A, Scholz J, Nobbe F, Vieregge P, Böhme V, Bamberg H
Department of Neurology, Medical University of Lübeck, Germany.
J Neurol Sci. 1995 Aug;131(2):183-9. doi: 10.1016/0022-510x(95)00110-n.
We could identify the MPTP-like compound and isoquinoline derivative N-methyl-norsalsolinol (2-MDTIQ) in cerebrospinal fluid (CSF) of patients with Parkinson's disease. The presence of 2-MDTIQ negatively correlated with the disease duration. In order to study the relationship between presence of 2-MDTIQ and dopamine metabolism, we examined 3-O-methyl-dopa (MDOPA) and homovanillic acid (HVA) levels in CSF of 15 normal control subjects and 34 patients with Parkinson's disease (PD). In the PD group in which 2-MDTIQ was detected, the HVA/MDOPA ratio was also negatively correlated with the duration of the disease and was increased when compared to patients without 2-MDTIQ. Since in both PD groups the daily L-dopa dose, the mean MDOPA levels, and the daily L-dopa dose/MDOPA ratio were nearly identical the results are not related to different L-dopa medications. In vitro experiments demonstrated 2-MDTIQ to inhibit monoamine oxidase activity in the caudate-putamen. These results suggest that 2-MDTIQ indicates an increased dopamine turnover in patients with PD. The enhanced metabolism at the beginning of the disease is not due to the presence of 2-MDTIQ since it inhibits dopamine metabolism. Thus, 2-MDTIQ, probably endogenously synthesized from dopamine, appears as a result of a compensatively activated dopaminergic system.
我们能够在帕金森病患者的脑脊液（CSF）中鉴定出MPTP样化合物和异喹啉衍生物N-甲基去甲索尔索林醇（2-MDTIQ）。2-MDTIQ的存在与疾病持续时间呈负相关。为了研究2-MDTIQ的存在与多巴胺代谢之间的关系，我们检测了15名正常对照者和34名帕金森病（PD）患者脑脊液中3-O-甲基多巴（MDOPA）和高香草酸（HVA）的水平。在检测到2-MDTIQ的PD组中，HVA/MDOPA比值也与疾病持续时间呈负相关，并且与未检测到2-MDTIQ的患者相比有所升高。由于在两个PD组中，每日左旋多巴剂量、平均MDOPA水平以及每日左旋多巴剂量/MDOPA比值几乎相同，因此结果与不同的左旋多巴用药无关。体外实验表明2-MDTIQ可抑制尾状核-壳核中的单胺氧化酶活性。这些结果表明，2-MDTIQ表明PD患者的多巴胺周转增加。疾病初期代谢增强并非由于2-MDTIQ的存在，因为它会抑制多巴胺代谢。因此，2-MDTIQ可能是由多巴胺内源性合成的，它是多巴胺能系统代偿性激活的结果。
