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帕金森病患者腰椎脑脊液中存在6,7-二羟基-1,2,3,4-四氢异喹啉甲基化物，即神经毒素异喹啉的衍生物。

Presence of methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF.

作者信息

Moser A, Kömpf D

机构信息

Department of Neurology, Medical University of Lübeck, F.R.G.

出版信息

Life Sci. 1992;50(24):1885-91. doi: 10.1016/0024-3205(92)90549-5.

DOI:10.1016/0024-3205(92)90549-5
PMID:1598074
Abstract

The TIQ derivatives 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (2-MDTIQ) and 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (1-MDTIQ, salsolinol) were identified the first time as possible endogenous neurotoxins in parkinsonian but not in normal human lumbar cerebrospinal fluid by high performance liquid chromatography with electrochemical detection. Additionally, MDTIQ analogues were incubated with a monoamine oxidase (MAO) assay. MAO was able to metabolize dose-dependently 2-MDTIQ, whereas 1-MDTIQ was not modified by the enzyme.

摘要

通过高效液相色谱电化学检测，首次在帕金森病患者而非正常人的腰椎脑脊液中鉴定出TIQ衍生物2-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉（2-MDTIQ）和1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉（1-MDTIQ，萨索林醇）可能是内源性神经毒素。此外，将MDTIQ类似物与单胺氧化酶（MAO）测定法一起孵育。MAO能够以剂量依赖的方式代谢2-MDTIQ，而1-MDTIQ未被该酶修饰。

相似文献

1
Presence of methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF.帕金森病患者腰椎脑脊液中存在6,7-二羟基-1,2,3,4-四氢异喹啉甲基化物，即神经毒素异喹啉的衍生物。
Life Sci. 1992;50(24):1885-91. doi: 10.1016/0024-3205(92)90549-5.
2
Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease.脑脊液中 N-甲基去甲索尔索林醇的存在：与帕金森病患者多巴胺代谢产物的相关性
J Neurol Sci. 1995 Aug;131(2):183-9. doi: 10.1016/0022-510x(95)00110-n.
3
Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.帕金森病患者和正常人脑内新型内源性胺类物质2-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉和1,2-二甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的存在情况。
Biochem Biophys Res Commun. 1991 Jun 14;177(2):603-9. doi: 10.1016/0006-291x(91)91831-v.
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N-methyl-norsalsolinol, an endogenous neurotoxin, inhibits tyrosine hydroxylase activity in the rat brain nucleus accumbens in vitro.N-甲基去甲索尔索林醇，一种内源性神经毒素，在体外抑制大鼠伏隔核中的酪氨酸羟化酶活性。
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The effect of N-methyl-norsalsolinol on monoamine oxidase of the rat caudate nucleus in vitro.
Neurochem Int. 1996 Jan;28(1):109-12. doi: 10.1016/0197-0186(95)00048-d.
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Neurotoxins: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 1,2,3,4-tetrahydroisoquinoline and 1-methyl-6,7-dihydroxy-tetrahydroisoquinoline as substrates for FAD-containing monooxygenase of porcine liver microsomes.
Biochem Pharmacol. 1992 Nov 17;44(10):2079-81. doi: 10.1016/0006-2952(92)90111-u.
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Increase in salsolinol level in the cerebrospinal fluid of parkinsonian patients is related to dementia: advantage of a new high-performance liquid chromatography methodology.帕金森病患者脑脊液中萨索林醇水平升高与痴呆有关：一种新型高效液相色谱方法的优势
Biol Psychiatry. 1997 Sep 15;42(6):514-8. doi: 10.1016/S0006-3223(96)00408-8.
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[Salsolinol, 3-O-methyl-dopa and homovanillic acid in the cerebrospinal fluid of Parkinson patients].[帕金森病患者脑脊液中的萨索利诺、3 - O - 甲基多巴和高香草酸]
Neurol Neurochir Pol. 1997 Sep-Oct;31(5):875-85.
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Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains.多巴胺衍生的萨索林醇衍生物作为内源性单胺氧化酶抑制剂：在人脑中的存在、代谢及功能
Neurotoxicology. 2004 Jan;25(1-2):193-204. doi: 10.1016/S0161-813X(03)00099-8.
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A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain.一种多巴胺能神经毒素，1(R)，2(N)-二甲基-6,7-二羟基-1,2,3,4-四氢异喹啉、N-甲基(R)萨索林醇及其氧化产物1,2(N)-二甲基-6,7-二羟基异喹啉鎓离子，在人脑黑质纹状体系统中蓄积。
Neurosci Lett. 1997 Feb 14;223(1):61-4. doi: 10.1016/s0304-3940(97)13389-4.

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