Draaijer P, de Leeuw P, Maessen J, van Hooff J, Leunissen K
University Hospital Maastricht, The Netherlands.
J Hum Hypertens. 1995 Apr;9(4):263-9.
We examined the reproducibility of dietary salt-sensitivity testing by studying the effects on blood pressure (BP) of low sodium intake (20 mmol/day) and high sodium intake (220 mmol/day) in 10 men with borderline hypertension on two separate occasions. A difference in mean arterial pressure of 8 mm Hg between the high salt and the low salt regimen was arbitrarily chosen to define salt sensitivity. In addition, the reproducibility of changes in renal haemodynamics and in humoral factors, such as plasma renin activity, plasma aldosterone, atrial natriuretic peptide and urinary dopa and dopamine excretion, on the alteration in sodium intake were studied. As far as changes in BP are concerned, there was perfect agreement between the two tests, because in the second investigation, all subjects were classified in the same category as before. The salt-induced changes in plasma atrial natriuretic peptide and in renal excretion of dopa (dihydroxyphenylalanine) and dopamine were repeatedly and consistently different between the salt-sensitive and the salt-resistant group. The study revealed no support for a role of renal haemodynamics or the renin-angiotensin-aldosterone system in the pathophysiology of salt-induced elevations of BP in salt-sensitive subjects.
我们通过在两个不同时间段研究低钠摄入（20 mmol/天）和高钠摄入（220 mmol/天）对10名临界高血压男性血压（BP）的影响，来检验饮食盐敏感性测试的可重复性。任意选择高盐和低盐方案之间平均动脉压相差8 mmHg来定义盐敏感性。此外，还研究了肾血流动力学变化以及诸如血浆肾素活性、血浆醛固酮、心房利钠肽和尿多巴胺及多巴排泄等体液因子随钠摄入量改变的可重复性。就血压变化而言，两次测试结果完全一致，因为在第二次调查中，所有受试者的分类与之前相同。盐敏感性和盐抵抗性组之间，盐诱导的血浆心房利钠肽以及肾多巴（二羟基苯丙氨酸）和多巴胺排泄的变化反复且始终存在差异。该研究未发现肾血流动力学或肾素 - 血管紧张素 - 醛固酮系统在盐敏感性受试者盐诱导的血压升高病理生理学中起作用的证据。
