Coleman J M, Hogg G G, Rosenfeld J V, Waters K D
Department of Clinical Microbiology, Royal Children's Hospital, Parkville, Victoria, Australia.
Neurosurgery. 1995 Apr;36(4):858-63. doi: 10.1227/00006123-199504000-00032.
Invasive aspergillosis of the central nervous system is a rare but well-described disease. There have been only a few reported survivors, and mortality exceeds 95% in the immunosuppressed host. We present a 2-year-old boy with acute lymphatic leukemia and multiple Aspergillus brain abscesses who was successfully treated with liposomal amphotericin B, itraconazole, and surgical excision of the abscesses. Liposomal amphotericin B is a new preparation that safely allows the attainment of significantly higher tissue levels with less toxicity than standard amphotericin B. The treatment of patients with invasive central nervous system aspergillosis is reviewed.
中枢神经系统侵袭性曲霉病是一种罕见但已有充分描述的疾病。仅有少数幸存者的报道，在免疫抑制宿主中死亡率超过95%。我们报告一名患有急性淋巴细胞白血病和多发曲霉菌性脑脓肿的2岁男孩，他通过脂质体两性霉素B、伊曲康唑及脓肿手术切除成功治愈。脂质体两性霉素B是一种新制剂，与标准两性霉素B相比，它能安全地达到显著更高的组织浓度且毒性更低。本文对侵袭性中枢神经系统曲霉病患者的治疗进行了综述。
