Sakai H, Tani Y, Shirasawa E, Shirao Y, Kawasaki K
Developmental Research Laboratories, Santen Pharmaceutical Co. Ltd., Osaka, Japan.
Ophthalmic Res. 1995;27(1):57-63. doi: 10.1159/000267571.
Development of electroretinographic alterations in 9-week-old experimental diabetic rats was studied for up to 6 weeks after a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). The amplitudes and the peak latencies of the a and b waves in the diabetic rats did not differ significantly from those in the control rats. In contrast, the diabetic rats showed a significantly smaller amplitude of the second oscillatory potential (OP) 6 weeks after STZ treatment, and furthermore significantly delayed OP peaks as early as 2-3 weeks after STZ treatment. Vitreous fluorophotometric abnormality developed 6 weeks after STZ treatment. None of the diabetic rats had fundus angiographic changes. These results suggest that hyperglycemia or its related changes rapidly affects the light-induced electrical activities of the retina.
研究单次腹腔注射链脲佐菌素（STZ，60mg/kg）后9周龄实验性糖尿病大鼠视网膜电图改变的发展情况，观察期长达6周。糖尿病大鼠a波和b波的振幅及峰潜伏期与对照大鼠相比无显著差异。相反，糖尿病大鼠在STZ治疗6周后第二振荡电位（OP）的振幅显著减小，且在STZ治疗后2 - 3周OP峰就明显延迟。STZ治疗6周后出现玻璃体荧光光度异常。所有糖尿病大鼠均无眼底血管造影改变。这些结果表明，高血糖或其相关变化会迅速影响视网膜的光诱导电活动。
