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SIN3通过两种不同的启动子元件来调控酵母中INO1基因的表达。

SIN3 works through two different promoter elements to regulate INO1 gene expression in yeast.

作者信息

Slekar K H, Henry S A

机构信息

Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

出版信息

Nucleic Acids Res. 1995 Jun 11;23(11):1964-9. doi: 10.1093/nar/23.11.1964.

DOI:10.1093/nar/23.11.1964
PMID:7596825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC306970/
Abstract

The SIN3 global regulatory factor affects expression of many yeast genes, including the phospholipid biosynthetic gene, INO1. Mutations in the SIN3 gene result in elevated levels of INO1 expression under conditions that normally confer full repression of INO1 transcription, indicating that SIN3 is a negative regulator of INO1. In this study, the INO1 promoter was analyzed for sequences that play a role in responding to SIN3-mediated repression. Two distinct promoter elements, the upstream repression sequence (URS1) and the INO1 upstream activation sequence (UASINO) both were found to be involved in enabling SIN3 to repress INO1 expression.

摘要

SIN3全局调控因子影响许多酵母基因的表达，包括磷脂生物合成基因INO1。SIN3基因突变导致INO1在通常完全抑制INO1转录的条件下表达水平升高，这表明SIN3是INO1的负调控因子。在本研究中，对INO1启动子进行了分析，以寻找在响应SIN3介导的抑制中起作用的序列。发现两个不同的启动子元件，即上游抑制序列（URS1）和INO1上游激活序列（UASINO），均参与使SIN3抑制INO1的表达。

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1
SIN3 works through two different promoter elements to regulate INO1 gene expression in yeast.SIN3通过两种不同的启动子元件来调控酵母中INO1基因的表达。
Nucleic Acids Res. 1995 Jun 11;23(11):1964-9. doi: 10.1093/nar/23.11.1964.
2
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本文引用的文献

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Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae.酿酒酵母早期减数分裂上游激活序列的二分结构。
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The INO1 promoter of Saccharomyces cerevisiae includes an upstream repressor sequence (URS1) common to a diverse set of yeast genes.酿酒酵母的INO1启动子包含一个多种酵母基因共有的上游阻遏序列（URS1）。
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INO2 and INO4 gene products, positive regulators of phospholipid biosynthesis in Saccharomyces cerevisiae, form a complex that binds to the INO1 promoter.INO2和INO4基因产物是酿酒酵母中磷脂生物合成的正调控因子，它们形成一个与INO1启动子结合的复合物。
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A pleiotropic phospholipid biosynthetic regulatory mutation in Saccharomyces cerevisiae is allelic to sin3 (sdi1, ume4, rpd1).酿酒酵母中一种多效性磷脂生物合成调控突变与sin3（sdi1、ume4、rpd1）等位。
Genetics. 1994 Feb;136(2):475-83. doi: 10.1093/genetics/136.2.475.
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An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3.Mxi1的氨基末端结构域介导抗Myc致癌活性，并与酵母转录抑制因子SIN3的同源物相互作用。
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Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.Mad-Max转录抑制是通过与酵母阻遏物Sin3的哺乳动物同源物形成三元复合物来介导的。
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Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes.酵母INO2和INO4螺旋-环-螺旋激活基因的自动调节表达对其靶基因产生协同调节作用。
Mol Cell Biol. 1995 Mar;15(3):1709-15. doi: 10.1128/MCB.15.3.1709.
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Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol-excreting mutants.酵母中肌醇生物合成的调控突变：肌醇分泌突变体的分离
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Activation of the yeast HO gene by release from multiple negative controls.通过从多种负调控中释放来激活酵母HO基因。
Cell. 1987 Feb 27;48(4):567-77. doi: 10.1016/0092-8674(87)90235-2.