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2匹马中盐酸林可霉素的超说明书用药。因对症治疗不足导致的菌群失调和致命并发症

[Off-label use of lincomycin hydrochloride in 2 horses. Dysbacteriosis and fatal complications due to inadequate symptomatic therapy].

作者信息

van Miert A S

机构信息

Vakgroep Veterinaire Basiswetenschappen, Faculteit Diergeneeskunde van de Universiteit Utrecht.

出版信息

Tijdschr Diergeneeskd. 1995 Jun 15;120(12):361-3.

PMID:7597685
Abstract

A lawyer inquired about the possible harmful effects of 'off-label use' of lincomycin in two trotting horses. From information in the relevant dossier it could be concluded that there was no direct indication to use antibiotics. In addition, mistakes were made in the medicinal treatment of horses, namely, the off-label use of lincomycin without prior consultation with the manufacturer, fluid and electrolyte replacement therapy not continued for long enough, and incorrect use of antipyretic analgesics. The intravenous administration of gentamicin to dehydrated patients is permissible only in combination with adequate administration of fluids and electrolytes.

摘要

一名律师询问了林可霉素在两匹小跑马中“超说明书用药”可能产生的有害影响。根据相关档案中的信息可以得出结论,没有使用抗生素的直接指征。此外,在马匹的药物治疗中存在失误,即未事先咨询制造商就超说明书使用林可霉素、液体和电解质替代疗法持续时间不够长以及解热镇痛药使用不当。仅在充分补充液体和电解质的情况下,才允许对脱水患者静脉注射庆大霉素。

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