Shaw M L, Carpenter J W, Leith D E
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
J Am Vet Med Assoc. 1995 Mar 15;206(6):833-6.
Carfentanil citrate, the only opioid approved in the United States for immobilizing large exotic animals, increasingly has been used to chemically restrain exotic horses, such as Prezwalski's horses (Equus przewalskii) and wild horses (E caballus). Because carfentanil's duration of action is long and renarcotization may develop 2 to 24 hours after administration of antagonists, a study was designed to compare the physiologic effects of opioid antagonists, using domestic horses chemically restrained with xylazine hydrochloride and carfentanil. The study was terminated after the initial 3 horses developed severe tachycardia and hypertension, which resulted in the death of 1 horse from pulmonary edema. Although it was possible that the clinical findings in these horses may have resulted from use of an inadequate dosage of carfentanil or xylazine, or both, analysis of the results more likely indicated that domestic and exotic horses may respond differently to carfentanil, and domestic horses may not be a good model for use in studies of carfentanil.
枸橼酸卡芬太尼是美国唯一被批准用于麻醉大型外来动物的阿片类药物，越来越多地被用于化学约束外来马匹，如普氏野马（Equus przewalskii）和野马（E caballus）。由于卡芬太尼的作用持续时间长，且在使用拮抗剂后2至24小时可能会出现再麻醉现象，因此设计了一项研究，以比较阿片类拮抗剂的生理效应，该研究使用盐酸赛拉嗪和卡芬太尼化学约束的家马。在最初的3匹马出现严重心动过速和高血压并导致1匹马因肺水肿死亡后，该研究终止。尽管这些马的临床症状可能是由于卡芬太尼或赛拉嗪剂量不足或两者兼而有之，但对结果的分析更有可能表明，家马和外来马对卡芬太尼的反应可能不同，家马可能不是用于卡芬太尼研究的良好模型。
