Dretler S P, Pfister R C, Newhouse J H
N Engl J Med. 1979 Feb 15;300(7):341-3. doi: 10.1056/NEJM197902153000704.
Recurrent renal stones associated with urinary infection were treated in eight kidneys in six patients by percutaneous nephrostomy and irrigation with hemiacidrin, a commercially available solution of organic acids and magnesium. The stones, presumably composed of triple phosphates (magnesium, ammonium and calcium phosphate), were completely dissolved in six kidneys; in two they were partially dissolved and subsequently recovered by other methods. No serious complications were encountered. The technic requires special precautions against perinephric and intravascular dissemination of infection, but it offers potentially effective therapy for certain kidney stones without the use of general anesthesia or operation.
6例患者的8个肾脏出现了与泌尿系统感染相关的复发性肾结石，采用经皮肾造瘘术并用半胱氨酸冲洗进行治疗，半胱氨酸是一种市售的有机酸和镁的溶液。这些结石可能由三联磷酸盐（磷酸镁、磷酸铵和磷酸钙）组成，在6个肾脏中完全溶解；在另外2个肾脏中部分溶解，随后通过其他方法取出。未出现严重并发症。该技术需要特别预防感染在肾周和血管内扩散，但它为某些肾结石提供了潜在有效的治疗方法，无需全身麻醉或手术。
