Garraway W M, Whisnant J P, Furlan A J, Phillips L H, Kurland L T, O'Fallon W M
N Engl J Med. 1979 Mar 1;300(9):449-52. doi: 10.1056/NEJM197903013000901.
A major decline in the incidence of stroke occurred in the population of Rochester, Minnesota, during the period 1945 to 1974. For every 100 first episodes of stroke that occurred per unit of population during the period 1945--49, only 55 occurred in the period 1970--74. Although the decline was present in both sexes and in all age groups, the reduction in rates was more pronounced in the elderly. There was no major change in age at onset. Analysis of cohorts born during successive five-year periods from 1865 to 1915 confirmed the decreasing incidence rate in all age groups.
1945年至1974年期间,明尼苏达州罗切斯特市人群中风发病率大幅下降。在1945 - 1949年期间,每单位人口中首次发生中风的病例为100例,而在1970 - 1974年期间,这一数字仅为55例。尽管男女及各年龄组均出现了下降,但老年人的发病率下降更为明显。发病年龄没有重大变化。对1865年至1915年期间连续五年出生队列的分析证实,所有年龄组的发病率都在下降。