Laur D F, Sinkovich J, Betley K
CRNA. 1995 Feb;6(1):21-5.
Morphine sulfate and methadone hydrochloride exhibit very different half-lives but are described as having an analgesic potency of one. The use of a drug like methadone may provide prolonged and constant analgesia in the perioperative setting. This double-blinded investigation used methadone and morphine intraoperatively and measured pain scores and narcotic requirements in the first 24 hours postoperatively. Thirty American Society of Anesthesiology (ASA) patients, physical status I through III, between the ages of 18 to 65 years were scheduled for orthopedic surgery and randomly assigned to receive morphine or methadone at 0.30 mg/kg. Fifteen patients received morphine and fifteen patients received methadone. There was no significant difference between the two groups in terms of age, height, weight, and ASA status. No statistically significant difference was observed among the two groups between the amount of analgesic requirements postoperatively or in the visual analogue scale pain score.
硫酸吗啡和盐酸美沙酮的半衰期差异很大，但都被描述为具有相同的镇痛效力。在围手术期使用美沙酮这类药物可能会提供持久且稳定的镇痛效果。这项双盲研究在术中使用了美沙酮和吗啡，并测量了术后头24小时的疼痛评分和麻醉药物需求量。30例美国麻醉医师协会（ASA）身体状况为I至III级、年龄在18至65岁之间的患者计划接受骨科手术，并随机分配接受0.30mg/kg的吗啡或美沙酮。15例患者接受吗啡，15例患者接受美沙酮。两组在年龄、身高、体重和ASA状况方面无显著差异。两组之间在术后镇痛药物需求量或视觉模拟评分法疼痛评分上均未观察到统计学上的显著差异。
