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Synthesis of sulfated cerebroside analogs having mimicks of ceramide and their anti-human immunodeficiency virus type 1 activities.

作者信息

Yoshida H, Ikeda K, Achiwa K, Hoshino H

机构信息

School of Pharmaceutical Sciences, University of Shizuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1995 Apr;43(4):594-602. doi: 10.1248/cpb.43.594.

DOI:10.1248/cpb.43.594
PMID:7600612
Abstract

Various sulfated cerebroside analogs, which are mimicks of cerebroside, have been prepared from per-O-acetylated D-glucose, per-O-acetylated D-galactose, and per-O-acetylated D-lactose with ethyleneglycol dodecyl ether, 3-docosyloxy-1-propanol, 2-hydroxymethyl-1,3-O-dimyristyl-1,3-propanediol, and L-serine diamide derivatives as ceramide moieties. The synthesized sulfated glycolipids showed anti-HIV-1 activities.

摘要

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