Takeuchi Y, Sunagawa M, Isobe Y, Hamazume Y, Noguchi T
Research Center Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.
Chem Pharm Bull (Tokyo). 1995 Apr;43(4):689-92. doi: 10.1248/cpb.43.689.
The stability and the degradation products of 1 beta-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution, pseudo-first-order degradation was observed, and good stability of meropenem in aqueous solution was demonstrated by the effect of 1 beta-methyl group against hydrolysis of beta-lactam ring. As degradation products, the beta-lactam hydrolyzed product and the dimer product resulting from intermolecular aminolysis of beta-lactam ring by the amine of the second molecule were described.
研究了1β-甲基碳青霉烯类美罗培南在水溶液中的稳定性及其降解产物。在pH 4 - 8的稀溶液中，观察到假一级降解，并且1β-甲基基团对β-内酰胺环水解的影响证明了美罗培南在水溶液中具有良好的稳定性。作为降解产物，描述了β-内酰胺水解产物以及第二个分子的胺对β-内酰胺环进行分子间氨解产生的二聚体产物。
