Farrer M, Albers C J, Neil H A, Adams P C, Laker M F, Alberti K G
Department of Cardiology, Medical School, University of Newcastle upon Tyne, UK.
Diabet Med. 1995 Apr;12(4):325-9. doi: 10.1111/j.1464-5491.1995.tb00486.x.
In a prospective study of 353 patients who had undergone coronary artery bypass graft surgery a 75 g oral glucose tolerance test was performed at 3 months and 12 months after surgery. Venous whole blood glucose and venous plasma glucose samples were assayed on a bench-top analyser. The World Health Organization diagnostic criteria for impaired glucose tolerance and diabetes mellitus were applied to venous whole blood glucose and venous plasma glucose measurements. The difference between the plasma and whole blood concentration of glucose was 0.79-0.86 mmol l-1 at a plasma glucose of 7.8 mmol l-1 and 1.22-1.24 mmol l-1 at a plasma glucose of 11.1 mmol l-1 (compared to 1.1 mmol l-1 by World Health Organization criteria at both cut-points). Despite this, in our subject population with a high prevalence of impaired glucose tolerance (20.3% at 3 months, 15.3% at 12 months) and diabetes mellitus (10.1% at 3 months and 12 months), there was no significant difference in the proportion classified impaired glucose tolerance or having diabetes mellitus using venous whole blood glucose compared to venous plasma glucose. We conclude that despite the minor anomaly between WHO diagnostic criteria based on venous whole blood glucose and venous plasma glucose measurements, these criteria are robust and give broadly comparable population prevalence of diabetes mellitus and impaired glucose tolerance irrespective of blood sample choice.
在一项针对353例行冠状动脉搭桥手术患者的前瞻性研究中，术后3个月和12个月时进行了75克口服葡萄糖耐量试验。使用台式分析仪测定静脉全血葡萄糖和静脉血浆葡萄糖样本。将世界卫生组织关于糖耐量受损和糖尿病的诊断标准应用于静脉全血葡萄糖和静脉血浆葡萄糖测量。当血浆葡萄糖为7.8 mmol/L时，血浆与全血葡萄糖浓度差为0.79 - 0.86 mmol/L，当血浆葡萄糖为11.1 mmol/L时，该差值为1.22 - 1.24 mmol/L（相比之下，世界卫生组织标准在两个切点处均为1.1 mmol/L）。尽管如此，在我们糖耐量受损患病率较高（3个月时为20.3%，12个月时为15.3%）和糖尿病患病率较高（3个月和12个月时均为10.1%）的研究对象群体中，使用静脉全血葡萄糖与静脉血浆葡萄糖来分类糖耐量受损或患有糖尿病的比例并无显著差异。我们得出结论，尽管基于静脉全血葡萄糖和静脉血浆葡萄糖测量的世界卫生组织诊断标准之间存在细微差异，但这些标准是可靠的，并且无论选择何种血样，糖尿病和糖耐量受损的总体患病率大致相当。
