Parrott R F, Vellucci S V, Forsling M L, Goode J A
Babraham Institute, Cambridge, UK.
Domest Anim Endocrinol. 1995 Apr;12(2):197-205. doi: 10.1016/0739-7240(94)00021-r.
Experimentally induced fever is accompanied by a variety of hormonal changes, and there is evidence to suggest that some of these responses may be mediated by prostaglandins. However, little is known about the endocrine effects of peripherally administered prostaglandins, especially in domesticated species. In this study, the effects of intravenous prostaglandin E2 (PGE2; 20 micrograms/kg) on deep body temperature and plasma concentrations of cortisol, lysine vasopressin (LVP), and growth hormone were investigated in prepubertal pigs (n = 6) prepared with venous catheters and sampled at 10-min intervals for 3 hr. PGE2-induced hyperthermia, which lasted for the duration of the study, was accompanied by a 70-min increase in cortisol and LVP concentrations. Moreover, this hyperthermic response was checked when LVP levels were high. These results indicate that a fever-inducing intravenous injection of PGE2 produced a marked anterior and posterior pituitary hormone response in growing pigs. Also, the transient increase in LVP may be correlated with a central action of the hormone, limiting the extent of the fever. In addition, because the majority of the animals exhibited mild hyperthermia (0.5 degrees C) under control conditions, the results suggest that, in a given population of pigs, there may be some animals that exhibit stress-induced hyperthermia.
实验性诱导发热伴随着多种激素变化，并且有证据表明其中一些反应可能由前列腺素介导。然而，关于外周给予前列腺素的内分泌效应知之甚少，尤其是在驯养动物中。在本研究中，对用静脉导管准备好的青春期前猪（n = 6）静脉注射前列腺素E2（PGE2；20微克/千克），并每隔10分钟采样一次，持续3小时，研究其对深部体温以及皮质醇、赖氨酸加压素（LVP）和生长激素血浆浓度的影响。PGE2诱导的体温过高在研究期间持续存在，同时皮质醇和LVP浓度增加了70分钟。此外，当LVP水平较高时，这种体温过高反应受到抑制。这些结果表明，静脉注射PGE2诱导发热在生长猪中引起了明显的垂体前叶和后叶激素反应。而且，LVP的短暂增加可能与该激素的中枢作用相关，限制了发热的程度。此外，由于大多数动物在对照条件下表现出轻度体温过高（0.5摄氏度），结果表明，在特定猪群中，可能存在一些表现出应激诱导体温过高的动物。
