Parrott R F, LLoyd D M
Department of Neurobiology, Babraham Institute, Cambridge, UK.
Physiol Behav. 1995 Jun;57(6):1051-5. doi: 10.1016/0031-9384(94)00343-4.
Three experiments were carried out to investigate stress hyperthermia in prepubertal pigs. Experiment 1 examined the effect of frustrative nonreward (psychological stress) on deep body temperature in animals (n = 7) trained to make operant responses for food following a 17.5-h period of deprivation. There was no change in body temperature when the feeders were switched off whereas there was a small increase (NS) during normal operant feeding that might be attributable to physical exertion. In Experiment 2, the effects of 15-min physical restraint (snaring) were examined in the same group of animals. This procedure induced a significant (p < 0.01) rise in core temperature that was completely abolished by prior administration of a cyclooxygenase inhibitor (indomethacin, 2 mg/kg given intravenously). The final experiment investigated the effects of snaring on plasma cortisol concentrations. Blood samples were taken from indwelling catheters in pigs (n = 5) subjected to 15-min restraint with, or without, indomethacin pretreatment. Snaring produced a significant (p < 0.001) increase in cortisol release that was not affected by the administration of indomethacin. These results suggest that snaring, a physical stress that may also have energy expenditure components, induces a prostaglandin-mediated hyperthermic response in the growing pig.
进行了三项实验来研究青春期前猪的应激性体温过高。实验1检测了挫折性无奖励（心理应激）对经过17.5小时禁食训练以做出获取食物的操作性反应的动物（n = 7）深部体温的影响。关闭喂食器时体温没有变化，而在正常操作性喂食期间有小幅升高（无统计学意义），这可能归因于体力消耗。在实验2中，对同一组动物检测了15分钟身体束缚（圈套）的影响。该操作导致核心体温显著升高（p < 0.01），预先静脉注射环氧化酶抑制剂（吲哚美辛，2 mg/kg）可完全消除这种升高。最后一项实验研究了圈套对血浆皮质醇浓度的影响。从接受15分钟束缚且有或没有吲哚美辛预处理的猪（n = 5）的留置导管采集血样。圈套导致皮质醇释放显著增加（p < 0.001），吲哚美辛给药对此无影响。这些结果表明，圈套这种可能也有能量消耗成分的身体应激，在生长猪中诱导了前列腺素介导的体温过高反应。
