[肝硬化患者胆囊胆汁中脂质、胆红素及金属元素的变化]

[Changes in lipids, bilirubin and metal elements in the gallbladder bile in patients with cirrhosis of the liver].

作者信息

Zhu J F, Shan L C, Chen W H

机构信息

General Hospital of Jinan Unit of People's Liberation Army.

出版信息

Zhonghua Nei Ke Za Zhi. 1994 Nov;33(11):767-9.

PMID:7600868

Abstract

The aim of this study is to observe the changes of bile elements in patients with cirrhosis of liver and to analyse the relationship with stone formation. The gallbladder bile in 24 patients with cirrhosis of liver was obtained with aspiration during operation. The levels of lipids, bilirubin and various metal elements such as potassium, sodium, calcium, magnesium, copper, iron, and zinc in the bile were determined. Elevated unconjugated bilirubin (UCB) level (P < 0.02) and decreased levels of total bile acid (TBA) (P < 0.001), total cholesterol (TC) (P < 0.001), phospholipids (PL) (P < 0.05) and bile viscosity (P < 0.001) were found. The levels of potassium, magnesium, copper and zinc in the bile decreased (all P values less than 0.001), while the level of iron increased (P < 0.02) significantly in cirrhotic patients. The results showed that there is an obvious tendency for gallbladder bile in cirrhotic patients to form pigment stones.

摘要

本研究旨在观察肝硬化患者胆汁成分的变化，并分析其与结石形成的关系。通过手术抽吸获取24例肝硬化患者的胆囊胆汁。测定胆汁中脂质、胆红素以及钾、钠、钙、镁、铜、铁、锌等各种金属元素的含量。结果发现，未结合胆红素（UCB）水平升高（P < 0.02），总胆汁酸（TBA）水平降低（P < 0.001），总胆固醇（TC）水平降低（P < 0.001），磷脂（PL）水平降低（P < 0.05），胆汁黏度降低（P < 0.001）。肝硬化患者胆汁中钾、镁、铜和锌的含量降低（所有P值均小于0.001），而铁含量显著升高（P < 0.02）。结果表明，肝硬化患者胆囊胆汁有明显形成色素结石的倾向。