Llobet J M, Colomina M T, Sirvent J J, Domingo J L, Corbella J
Laboratory of Toxicology and Biochemistry, Rovira i Virgili University, Reus, Spain.
Fundam Appl Toxicol. 1995 Apr;25(1):45-51. doi: 10.1006/faat.1995.1038.
The reproductive toxicology of aluminum was studied in mice. Adult male mice were treated intraperitoneally with aluminum nitrate at doses of 0, 50, 100, and 200 mg/kg/day for 4 weeks before mating with untreated females. Decreased body weight was seen in all aluminum-treated groups. Decreased pregnancy rate was observed in the females mated with males previously treated with 100 or 200 mg/kg/day of aluminum nitrate. High-dose male mice showed significantly decreased testicular and epididymal weights, as well as significant decreases in testicular and spermatid counts and epididymal sperm counts. Spermatid counts were also reduced at 100 mg/kg/day. However, the sperm motility was unaffected, and the percentages of morphological normal spermatozoa in all mice exposed to aluminum were comparable to the values in control mice. Histological changes, including necrosis of spermatocytes/spermatids, were observed in the testes of male mice treated with 100 and 200 mg/kg/day of aluminum nitrate, whereas the tubular diameters were unaffected by aluminum administration. The current study demonstrates adverse effects of parenteral aluminum exposure on the mouse male reproductive system. The "no observable adverse effect level" (NOAEL) was 50 mg/kg/day.
在小鼠中研究了铝的生殖毒性。成年雄性小鼠在与未处理的雌性小鼠交配前4周，腹腔注射剂量为0、50、100和200mg/kg/天的硝酸铝。所有铝处理组的体重均下降。与先前用100或200mg/kg/天硝酸铝处理过的雄性小鼠交配的雌性小鼠，妊娠率降低。高剂量雄性小鼠的睾丸和附睾重量显著下降，睾丸和精子细胞计数以及附睾精子计数也显著减少。在100mg/kg/天剂量下，精子细胞计数也减少。然而，精子活力未受影响，所有暴露于铝的小鼠中形态正常精子的百分比与对照小鼠的值相当。在用100和200mg/kg/天硝酸铝处理的雄性小鼠睾丸中观察到组织学变化，包括精母细胞/精子细胞坏死，而铝给药对管径无影响。当前研究表明，经肠胃外暴露于铝对小鼠雄性生殖系统有不良影响。“无明显有害作用水平”（NOAEL）为50mg/kg/天。
