Geratz J D, Pryzwansky K B, Anderle S K, Tidwell R R
Department of Pathology, School of Medicine, University of North Carolina at Chapel Hill 27599, USA.
Inflammation. 1995 Apr;19(2):221-31. doi: 10.1007/BF01534463.
This study has shown that cyclosporine A (CyA), under certain conditions, is a powerful inhibitor of intravascular and extravascular monocyte/macrophage accumulation. Experiments were carried out in Lewis rats in which intravenous injection of particulate glucan calls forth a striking granulomatous response in lung, liver, and spleen and produces a marked stimulation of splenic erythro- and myelopoiesis. In agreement with the results of others, there was also a considerable elevation in monocyte/macrophage chemoattractant levels in the bronchoalveolar lavage fluid, which is held to be a key reaction in the pathogenesis of the histologic lesions. Treatment of the animals with subcutaneous injections of CyA prevented the rise in the chemoattractant activity and suppressed the granulomatous organ infiltration as well as the splenic hemopoiesis. The findings supply new insights into the activities of CyA and would support its clinical use in macrophage-dominated diseases.
本研究表明，在某些条件下，环孢素A（CyA）是血管内和血管外单核细胞/巨噬细胞积聚的强效抑制剂。实验在Lewis大鼠中进行，静脉注射颗粒状葡聚糖会在肺、肝和脾中引发显著的肉芽肿反应，并对脾红细胞生成和骨髓生成产生明显刺激。与其他研究结果一致，支气管肺泡灌洗液中的单核细胞/巨噬细胞趋化因子水平也有相当程度的升高，这被认为是组织学病变发病机制中的关键反应。皮下注射CyA对动物进行治疗可防止趋化因子活性升高，并抑制肉芽肿性器官浸润以及脾造血。这些发现为CyA的作用提供了新的见解，并支持其在巨噬细胞主导疾病中的临床应用。
