Francès C, Le Tonquèze M, Salohzin K V, Kalashnikova L A, Piette J C, Godeau P, Nasonov E L, Youinou P
Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
J Am Acad Dermatol. 1995 Jul;33(1):64-8. doi: 10.1016/0190-9622(95)90012-8.
Sneddon's syndrome consists of widespread livedo reticularis and ischemic cerebral manifestations. Its pathogenesis remains unclear. Endothelial cells could be the primary target tissue.
Our aim was to determine the prevalence of anti-endothelial cell antibodies (AECA) in a large series of patients with Sneddon's syndrome. The results were compared with those of three groups of control subjects: 39 patients with active periarteritis nodosa, 20 patients hospitalized for stroke without livedo, and 28 healthy persons.
AECA were detected with enzyme-linked immunosorbent assay with hybrid cells (EA.hy926) before and after absorption on epithelial cells (A 549/8) to avoid false positivity from antibodies reacting with membranous epithelial antigens.
Twenty-two patients with Sneddon's syndrome had AECA (35%). Of the control subjects, 11 patients with active periarteritis nodosa (28%), 1 of 20 patients with a recent stroke without livedo, and no healthy persons had AECA.
AECA were frequently found in patients with Sneddon's syndrome, in contrast to the patients with stroke without livedo. The clinical significance and involvement of these antibodies in the pathogenesis of endothelial lesions in Sneddon's syndrome remain to be ascertained.
斯内登综合征表现为广泛的网状青斑和缺血性脑损害。其发病机制尚不清楚。内皮细胞可能是主要的靶组织。
我们的目的是确定一大组斯内登综合征患者中抗内皮细胞抗体（AECA）的患病率。将结果与三组对照受试者进行比较：39例活动性结节性多动脉炎患者、20例无网状青斑的中风住院患者和28名健康人。
采用酶联免疫吸附试验，用杂交细胞（EA.hy926）检测AECA，并在上皮细胞（A 549/8）上吸附前后进行检测，以避免与膜上皮抗原反应的抗体产生假阳性。
22例斯内登综合征患者存在AECA（35%）。在对照受试者中，11例活动性结节性多动脉炎患者（28%）、20例近期无网状青斑中风患者中的1例以及无健康人存在AECA。
与无网状青斑的中风患者相比，斯内登综合征患者中经常发现AECA。这些抗体在斯内登综合征内皮病变发病机制中的临床意义和作用仍有待确定。
